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1-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]quinoline is a complex organic compound with the molecular formula C18H13N3O. It features a quinoline ring, which is a fused six- and five-membered ring system, and a triazole ring, which is a five-membered ring containing three nitrogen atoms. The compound also has a 4-methoxyphenyl group attached to the quinoline ring, which introduces a methoxy substituent at the para position of the phenyl ring. This chemical structure is of interest in medicinal chemistry and may have potential applications in the development of new drugs due to its unique properties and interactions with biological targets.

2693-40-5

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2693-40-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2693-40-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,9 and 3 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2693-40:
(6*2)+(5*6)+(4*9)+(3*3)+(2*4)+(1*0)=95
95 % 10 = 5
So 2693-40-5 is a valid CAS Registry Number.

2693-40-5Downstream Products

2693-40-5Relevant academic research and scientific papers

Nitroalkanes as electrophiles: Synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity

Aksenov, Alexander V.,Aksenov, Dmitrii A.,Aksenov, Nicolai A.,Arutiunov, Nikolai A.,Du, Liqin,Kirilov, Nikita K.,Kornienko, Alexander,Maslivetc, Vladimir,Rubin, Michael,Zhao, Zhenze

, p. 6651 - 6664 (2020)

We discovered a reaction of nitroalkanes with 2-hydrazinylquinolines, 2-hydrazinylpyridines and bis-2,4-dihydrazinylpyrimidines in polyphosphoric acid (PPA) affording 1,2,4-triazolo[4,3-a]quinolines, 1,2,4-triazolo[4,3-a]pyridines and bis[1,2,4]triazolo[4,3-a:4′,3′-c]pyrimidines, respectively. The reaction expands the scope of heterocyclic annulations involving phosphorylated nitronates, believed to be the electrophilic intermediates formed from nitroalkanes in PPA. Several of the synthesized triazoles showed promising anticancer activity by inducing differentiation in neuroblastoma cancer cells. Due to the urgent need for novel differentiation agents for neuroblastoma therapy, this finding warrants further evaluation of this class of compounds against neuroblastoma.

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