269392-82-7Relevant academic research and scientific papers
Zinc triflate catalyzed facile synthesis of novel 1,2,4-triazolinone derivatives using 3-Arylsydnone as synthon
Dorababu, Atukuri,Kamble, Ravindra R.,Kattimani, Pramod P.
, p. 510 - 517 (2013/08/23)
A series of novel tetrazoles (4a-k) and thiazolidinones (6a-k) appended to 2-Aryl-1,2,4-triazolin-3-ones were efficiently synthesized from 3-Arylsydnones (1a-k) in excellent yields using Zinc triflate as catalyst.
Facile TICl4-catalyzed synthesis of novel 1,2,4-triazoles appended to thiazoles
Gireesh,Kamble,Hunnur,Taj,Kariduraganavar
scheme or table, p. 877 - 885 (2012/04/04)
The reaction of sydnone-derived 3-aryl-5-methyl-1,3,4-oxadiazol-2(3H)-ones with thiourea and α-bromoacetophenone derivatives in the presence of a catalytic amount of TiCl4 produces 2-aryl-4-(4-aryl-1,3-thiazol-2-yl) -5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-ones. The title compounds were screened for their antibacterial and antifungal activity. The toxicity of the compounds was evaluated in terms of mutagenicity, tumorigenicity, and reproductive effects. The drug-relevant properties (ClogP, drug-likeness, and drug score) were calculated, and the structure-activity relationship was discussed.
Transformation of the sydnone ring into oxadiazolinones. A convenient one-pot synthesis of 3-aryl-5-methyl-1,3,4-oxadiazolin-2-ones from 3- arylsydnones and their antimicrobial activity
Mallur, Shanta G.,Badami, Bharati V.
, p. 65 - 67 (2007/10/03)
3-Arylsydnones (Ia-u) have been converted into the corresponding 3-aryl- 5-methyl-1,3,4-oxadiazolin-2-ones (IIIa-u) by a single-step reaction with bromine in acetic anhydride. In the preliminary screening of all these compounds, the halogen-substituted de
