269396-59-0 Usage
Uses
Used in Medicinal Chemistry:
Boc-(R)-3-Amino-4-(3,4-difluoro-phenyl)-butyric acid is used as a building block for the development of new pharmaceuticals due to its unique structural features and the presence of the Boc protecting group, which facilitates the synthesis of complex organic molecules.
Used in Drug Design:
In the pharmaceutical industry, Boc-(R)-3-Amino-4-(3,4-difluoro-phenyl)-butyric acid is used as a key intermediate in the synthesis of drug candidates, particularly those targeting specific biological pathways or interactions, owing to its difluoro-phenyl group.
Used in Organic Synthesis:
Boc-(R)-3-Amino-4-(3,4-difluoro-phenyl)-butyric acid is employed as a protected amino acid derivative in organic synthesis, where the Boc group is strategically used to prevent unwanted side reactions during the synthesis process.
Used in Research and Development:
In the field of research and development, Boc-(R)-3-Amino-4-(3,4-difluoro-phenyl)-butyric acid serves as a valuable compound for studying the effects of structural modifications on biological activity and for exploring novel therapeutic approaches.
Check Digit Verification of cas no
The CAS Registry Mumber 269396-59-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,3,9 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 269396-59:
(8*2)+(7*6)+(6*9)+(5*3)+(4*9)+(3*6)+(2*5)+(1*9)=200
200 % 10 = 0
So 269396-59-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H19F2NO4/c1-15(2,3)22-14(21)18-10(8-13(19)20)6-9-4-5-11(16)12(17)7-9/h4-5,7,10H,6,8H2,1-3H3,(H,18,21)(H,19,20)/t10-/m1/s1
269396-59-0Relevant academic research and scientific papers
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
