269396-77-2 Usage
Uses
Used in Pharmaceutical Research and Development:
Boc-(R)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is used as a building block in the synthesis of peptide drugs for its potential applications in the treatment of various medical conditions. Its specific structure, including the Boc-protecting group and the trifluoromethyl-phenyl functional group, makes it valuable for creating novel drug candidates with improved properties and bioavailability.
Used in Drug Discovery:
In the field of drug discovery, Boc-(R)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is utilized for its chirality and unique pharmacological activity due to its (R)-configuration. This feature allows researchers to explore its potential in developing new therapeutic agents with enhanced efficacy and selectivity.
Used in Medicinal Chemistry:
Boc-(R)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is employed in medicinal chemistry as a key component in the design and synthesis of new pharmaceutical compounds. Its unique structural features enable the development of drugs with targeted actions and reduced side effects, contributing to the advancement of personalized medicine.
Used in Drug Synthesis:
In the synthesis of drugs, Boc-(R)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid serves as an essential intermediate, facilitating the creation of complex molecular structures with specific therapeutic properties. Its presence in the synthesis process can lead to the development of innovative medications with improved pharmacokinetics and pharmacodynamics.
Overall, Boc-(R)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is a versatile and important chemical compound in the pharmaceutical industry, with applications spanning from drug discovery and development to medicinal chemistry and drug synthesis. Its unique structural features and chirality make it a promising candidate for the creation of novel and effective therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 269396-77-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,3,9 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 269396-77:
(8*2)+(7*6)+(6*9)+(5*3)+(4*9)+(3*6)+(2*7)+(1*7)=202
202 % 10 = 2
So 269396-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H20F3NO4/c1-15(2,3)24-14(23)20-11(9-13(21)22)8-10-6-4-5-7-12(10)16(17,18)19/h4-7,11H,8-9H2,1-3H3,(H,20,23)(H,21,22)/t11-/m1/s1
269396-77-2Relevant academic research and scientific papers
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
