269398-80-3 Usage
Uses
Used in Pharmaceutical Research:
BOC-(R)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID is used as a chiral building block for the synthesis of complex organic molecules, particularly in the development of new drugs and pharmaceuticals. Its unique structure and functional groups contribute to the creation of novel compounds with potential therapeutic applications.
Used in Peptide Synthesis:
In the field of peptide synthesis, BOC-(R)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID is utilized as a protected amino acid, where the BOC group serves to protect the amino functionality during the synthesis process. This protection allows for selective reactions to occur, facilitating the assembly of peptide sequences with greater precision and control.
Used in Drug Development:
BOC-(R)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID is employed as a key intermediate in the development of new drugs, leveraging its unique properties to enhance the pharmacological profiles of potential therapeutic agents. Its role in drug development may include improving drug efficacy, selectivity, or stability.
Used in Organic Chemistry Research:
In the broader context of organic chemistry, BOC-(R)-3-AMINO-4-(2-METHYL-PHENYL)-BUTYRIC ACID is used as a reagent or substrate in various chemical reactions, enabling the exploration of new reaction pathways and the synthesis of novel organic compounds for a range of applications, from materials science to medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 269398-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,3,9 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 269398-80:
(8*2)+(7*6)+(6*9)+(5*3)+(4*9)+(3*8)+(2*8)+(1*0)=203
203 % 10 = 3
So 269398-80-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H23NO4/c1-11-7-5-6-8-12(11)9-13(10-14(18)19)17-15(20)21-16(2,3)4/h5-8,13H,9-10H2,1-4H3,(H,17,20)(H,18,19)/t13-/m1/s1
269398-80-3Relevant academic research and scientific papers
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
