269726-77-4 Usage
Uses
Used in Pharmaceutical Industry:
Boc-(R)-3-Amino-4-(4-trifluoromethyl-phenyl)-butyric acid is used as a building block for the synthesis of various organic compounds and pharmaceutical drugs. Its structural properties and reactivity make it a valuable component in the development of potential drug candidates.
Used in Chemical Synthesis:
In chemical synthesis, Boc-(R)-3-Amino-4-(4-trifluoromethyl-phenyl)-butyric acid is used as a protected amine intermediate. The Boc group attached to the nitrogen atom provides protection for the amine group during chemical reactions, enabling selective functionalization of other parts of the molecule.
Used in Drug Development:
Boc-(R)-3-Amino-4-(4-trifluoromethyl-phenyl)-butyric acid is used as a key intermediate in the development of potential drug candidates. Its unique structural properties and reactivity contribute to the design and synthesis of novel pharmaceutical compounds with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 269726-77-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,7,2 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 269726-77:
(8*2)+(7*6)+(6*9)+(5*7)+(4*2)+(3*6)+(2*7)+(1*7)=194
194 % 10 = 4
So 269726-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H20F3NO4/c1-15(2,3)24-14(23)20-12(9-13(21)22)8-10-4-6-11(7-5-10)16(17,18)19/h4-7,12H,8-9H2,1-3H3,(H,20,23)(H,21,22)/t12-/m1/s1
269726-77-4Relevant academic research and scientific papers
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
