269726-80-9 Usage
Uses
Used in Pharmaceutical Industry:
Boc-(R)-3-Amino-4-(2-cyano-phenyl)-butyric acid is used as a building block for potential drug candidates due to its unique structure and reactivity. It plays a crucial role in the development of new pharmaceuticals, particularly in the synthesis of peptide-based drugs and other bioactive molecules.
Used in Peptide Synthesis:
In the field of organic chemistry, Boc-(R)-3-Amino-4-(2-cyano-phenyl)-butyric acid is utilized as a key component in peptide synthesis. Its Boc protecting group ensures the selective protection of the amino group during the synthesis process, facilitating the formation of complex peptide sequences with high purity and yield.
Used in Materials Science:
Boc-(R)-3-Amino-4-(2-cyano-phenyl)-butyric acid has potential applications in the development of new materials. Its unique chemical structure allows for the creation of novel materials with specific properties, such as improved stability, reactivity, or biocompatibility, which can be utilized in various industries.
Used in Biological Research:
Boc-(R)-3-Amino-4-(2-cyano-phenyl)-butyric acid is also employed in biological research to investigate biological processes and pathways. Its ability to interact with various biomolecules and its potential to modulate biological activities make it a valuable tool for understanding complex biological systems and discovering new therapeutic targets.
Check Digit Verification of cas no
The CAS Registry Mumber 269726-80-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,7,2 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 269726-80:
(8*2)+(7*6)+(6*9)+(5*7)+(4*2)+(3*6)+(2*8)+(1*0)=189
189 % 10 = 9
So 269726-80-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H20N2O4/c1-16(2,3)22-15(21)18-13(9-14(19)20)8-11-6-4-5-7-12(11)10-17/h4-7,13H,8-9H2,1-3H3,(H,18,21)(H,19,20)/t13-/m1/s1
269726-80-9Relevant academic research and scientific papers
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
