269726-83-2 Usage
Uses
Used in Pharmaceutical Synthesis:
BOC-(R)-3-AMINO-4-(3-CYANO-PHENYL)-BUTYRIC ACID is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and the BOC protecting group make it a valuable component in the development of new drugs with specific therapeutic properties.
Used in Peptide Synthesis:
In the field of peptide chemistry, BOC-(R)-3-AMINO-4-(3-CYANO-PHENYL)-BUTYRIC ACID is utilized as a building block for the creation of peptide sequences. Its incorporation into peptide chains allows for the exploration of novel bioactive peptides with potential applications in medicine and biotechnology.
Used in Biochemical Research:
BOC-(R)-3-AMINO-4-(3-CYANO-PHENYL)-BUTYRIC ACID is employed as a research tool in biochemical studies. Its unique chemical properties and reactivity make it suitable for investigating various biological processes and mechanisms, contributing to a deeper understanding of molecular interactions and pathways.
Used in Drug Development:
As a building block for new drug creation, BOC-(R)-3-AMINO-4-(3-CYANO-PHENYL)-BUTYRIC ACID plays a crucial role in the pharmaceutical industry. Its versatility and the ability to be modified and incorporated into various molecular frameworks make it an essential component in the design and synthesis of innovative therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 269726-83-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,7,2 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 269726-83:
(8*2)+(7*6)+(6*9)+(5*7)+(4*2)+(3*6)+(2*8)+(1*3)=192
192 % 10 = 2
So 269726-83-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H20N2O4/c1-16(2,3)22-15(21)18-13(9-14(19)20)8-11-5-4-6-12(7-11)10-17/h4-7,13H,8-9H2,1-3H3,(H,18,21)(H,19,20)/t13-/m1/s1
269726-83-2Relevant academic research and scientific papers
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
