2698-43-3

Usage

InChI:InChI=1/C10H5FN2/c11-10-4-2-1-3-9(10)5-8(6-12)7-13/h1-5H

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 109-77-3 malononitrile 
• 446-51-5 2-fluorobenzyl alcohol 

Downstream Products

• 919475-04-0 dimethyl 2,2-dicyano-3-(2-fluorophenyl)cyclopropane-1,1-dicarboxylate 
• 1239019-71-6 (S)-ethyl 4,4-dicyano-5-(2-fluorophenyl)cyclopent-1-enecarboxylate 
• 338965-16-5 2-(2-fluorobenzyl)malononitrile 
• 1285689-74-8 4-(2-fluorobenzyl)-1H-pyrazole-3,5-diamine 
• 1316040-88-6 6-amino-5-cyano-4-(2-fluorophenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole 
• 1350892-59-9 C₁₇H₁₀F₂N₂O 
• 1431621-25-8 6-amino-1-((1,3-diphenyl-1H-pyrazole-4-yl)methyleneamino)-4-(2-fluorophenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 89607-35-2 6-amino-4-(2-fluorophenyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 89607-52-3 2-[(2-Fluoro-phenyl)-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)-methyl]-malononitrile 

Relevant academic research and scientific papers

Preparation of a Pickering emulsion by modification of an amine-functionalized graphene oxide surface with organosilane: Efficient catalyst for the Knoevenagel condensation of malononitrile with aldehydes at mild temperature

In this study, a series of Pickering emulsions for catalysis of Knoevenagel condensations of malononitrile with aldehydes were prepared by surface modification of amine-functionalized graphene oxide (GO-NH2) with trimethoxymethylsilane (MTMS).

Synthesis, structure, and catalytic properties of a copper(II) coordination polymer material constructed from 5-nitro-1,2,3-benzenetricarboxylic acid and bis(4-pyridylformyl)piperazine mixed ligands

One three-dimensional coordination polymer material, {[Cu3(nbta)2(bpfp)2(H2O)2](H2O)2}n (H3nbta = 5-nitro-1,2,3-benzenetricarboxylic acid, bpfp = bis(4-pyri

Unexpected polymorphism during a catalyzed mechanochemical Knoevenagel condensation

The transformation of a base-catalyzed, mechano-assisted Knoevenagel condensation of mono-fluorinated benzaldehyde derivatives (p-, m-, o-benzaldehyde) with malonodinitrile was investigated in situ and in real time. Upon milling, the para-substituted prod

Amine Functionalized Graphene Oxide Stabilized Pickering Emulsion for Highly Efficient Knoevenagel Condensation in Aqueous Medium

Abstract: A Pickering emulsion catalytic system was developed using amphiphilic amine-functionalized graphene oxide (GO-NH2) for a Knoevenagel condensation in aqueous medium instead of organic solvent. The properties of GO-NH2 and th

New Pyrano-4H-benzo[g]chromene-5,10-diones with Antiparasitic and Antioxidant Activities

New pyranonaphthoquinone derivatives were synthesized and investigated for their activity against Trypanosoma brucei, Leishmania major, and Toxoplasma gondii parasites. The pentafluorophenyl derivative was efficacious against T. brucei with single digit m

Phosphine-Catalyzed (4 + 2) Annulation of δ-Sulfonamido-Substituted Enones with 1,1-Dicyanoalkenes: Synthesis of Piperidine Derivatives

The δ-sulfonamido-substituted enones were employed as phosphine acceptor in phosphine-catalyzed (4 + 2) annulation of 1,1-dicyanoalkenes. They served as a four-membered synthon to react with 1,1-dicyanoalkenes under mild reaction conditions, producing pip

Johnson-Corey-Chaykovsky fluorocyclopropanation of double activated alkenes: Scope and limitations

Johnson-Corey-Chaykovsky fluorocyclopropanation of double activated alkenes utilizing S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium tetrafluoroborate is an efficient approach to obtain a range of monofluorocyclopropane derivatives. So far, fluoromethylsulfonium salts have displayed the broadest scope for direct fluoromethylene transfer. In contrast to more commonly used fluorohalomethanes or freon derivatives, diarylfluoromethylsulfonium salts are bench stable, easy-to use reagents useful for the direct transfer of a fluoromethylene group to alkenes giving access to the challenging products-fluorocyclopropane derivatives. Interplay between the reactivity of the starting materials and stability of the fluorocyclopropanes formed determines the outcome of the process.

Manganese-organic framework assembled by 5-((4′-(tetrazol-5″-yl)benzyl)oxy)isophthalic acid: A solvent-free catalyst for the formation of carbon–carbon bond

A new three-dimensional manganese-based metal–organic framework Mn4L2(HL)(H2O)5, (1), based on semi-rigid 5-((4′-(tetrazol-5′’-yl)benzyl)oxy)isophthalic acid ligand (H3L) have been prepared and charac

Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel α-glucosidase inhibitors

Inhibition of α-glucosidase enzyme is of prime importance for the treatment of diabetes mellitus (DM). Apart of many organic scaffolds, pyridine based compounds have previously been reported for wide range of bioactivities. The current study reports a series of pyridine based synthetic analogues for their α-glucosidase inhibitory potential assessed by in vitro, kinetics and in silico studies. For this purpose, 2-amino-4-aryl-6-(phenylthio)pyridine-3,5-dicarbonitriles 1–28 were synthesized and subjected to in vitro screening. Several analogs, including 1–3, 7, 9, 11–14, and 16 showed many folds increased inhibitory potential in comparison to the standard acarbose (IC50 = 750 ± 10 μM). Interestingly, compound 7 (IC50 = 55.6 ± 0.3 μM) exhibited thirteen-folds greater inhibition strength than the standard acarbose. Kinetic studies on most potent molecule 7 revealed a competitive type inhibitory mechanism. In silico studies have been performed to examine the binding mode of ligand (compound 7) with the active site residues of α-glucosidase enzyme.