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Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid that enhances membrane permeability compared to poly-L-lysine. It has a variety of applications, including drug delivery, neuroprotection, and the development of anticancer vaccines. PLA is particularly effective in promoting antigen-presenting cells (APCs) to generate T cells and elicit immunostimulant functionality when used in peptide vaccines.

26982-20-7

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26982-20-7 Usage

Uses

Used in Biodegradable Capsules:
Poly-L-arginine hydrochloride is used as a polyelectrolyte solution in the synthesis of biodegradable capsules. This application takes advantage of its ability to enhance membrane permeability, allowing for controlled release of encapsulated substances.
Used in Layer by Layer (LbL) Assembly:
PLA is used as a layer constituent in the preparation of layer by layer (LbL) assembly of multilayer biodegradable shells. This technique enables the creation of complex structures with tailored properties for various applications, such as drug delivery or tissue engineering.
Used in C-reactive Protein Assays:
Poly-L-arginine hydrochloride is used in assays for the determination of binding activity of C-reactive protein for polycationic ligands. This application is crucial for understanding the interactions between C-reactive protein and potential therapeutic agents.
Used in RNA Complex Formation:
PLA is used to generate a complex with stimulatory RNA, such as in neutrophils. This complex formation can enhance the delivery and functionality of RNA molecules in various cellular processes.
Used in Ribosomal RNA Transfection:
Poly-L-arginine hydrochloride is used in the transfection of ribosomal RNA into human monocytic THP-1 cells. This application can facilitate the study of RNA function and its role in cellular processes.
Used in Alginate Capsule Bead Coating:
PLA is used for coating alginate capsule beads, which can improve the stability and bioavailability of encapsulated substances, as well as enhance their targeted delivery to specific cells or tissues.

Biochem/physiol Actions

Poly-L-arginine (PLA) possesses anti-bacterial activity. It has a greater capacity to enhance membrane permeability. PLA at lower concentration enhances cell proliferation and at higher concentration acts as antiproliferative agent.

Check Digit Verification of cas no

The CAS Registry Mumber 26982-20-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,9,8 and 2 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 26982-20:
(7*2)+(6*6)+(5*9)+(4*8)+(3*2)+(2*2)+(1*0)=137
137 % 10 = 7
So 26982-20-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H38N12O4/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28)/t10-,11-,12-/m0/s1

26982-20-7 Well-known Company Product Price

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  • Sigma

  • (P3892)  Poly-L-argininehydrochloride  mol wt >70,000

  • 26982-20-7

  • P3892-10MG

  • 544.05CNY

  • Detail
  • Sigma

  • (P3892)  Poly-L-argininehydrochloride  mol wt >70,000

  • 26982-20-7

  • P3892-50MG

  • 1,578.33CNY

  • Detail
  • Sigma

  • (P3892)  Poly-L-argininehydrochloride  mol wt >70,000

  • 26982-20-7

  • P3892-100MG

  • 2,724.93CNY

  • Detail
  • Sigma

  • (P7762)  Poly-L-argininehydrochloride  mol wt 15,000-70,000

  • 26982-20-7

  • P7762-10MG

  • 554.58CNY

  • Detail
  • Sigma

  • (P7762)  Poly-L-argininehydrochloride  mol wt 15,000-70,000

  • 26982-20-7

  • P7762-50MG

  • 1,601.73CNY

  • Detail
  • Sigma

  • (P7762)  Poly-L-argininehydrochloride  mol wt 15,000-70,000

  • 26982-20-7

  • P7762-100MG

  • 2,771.73CNY

  • Detail
  • Sigma

  • (P4663)  Poly-L-argininehydrochloride  mol wt 5,000-15,000

  • 26982-20-7

  • P4663-10MG

  • 655.20CNY

  • Detail
  • Sigma

  • (P4663)  Poly-L-argininehydrochloride  mol wt 5,000-15,000

  • 26982-20-7

  • P4663-50MG

  • 1,903.59CNY

  • Detail
  • Sigma

  • (P4663)  Poly-L-argininehydrochloride  mol wt 5,000-15,000

  • 26982-20-7

  • P4663-100MG

  • 3,274.83CNY

  • Detail

26982-20-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Arg dihydrochloride

1.2 Other means of identification

Product number -
Other names POLY-L-ARGININE HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:26982-20-7 SDS

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