2700-46-1Relevant academic research and scientific papers
Lactones; XIII. Grignard Reaction Followed by Phase-Transfer Oxidation: A Convenient Synthesis of γ,γ-Disubstituted γ-Butyrolactones from γ-Butyrolactone
Lehmann, Jochen,Marquardt, Norbert
, p. 1064 - 1067 (2007/10/02)
Grignard reaction of γ-butyrolactones, followed by oxidation of the resulting reaction mixture produces symmetrically γ,γ-dialkylated diarylated γ-butyrolactones.Phase transfer oxidation with potassium permanganate in benzene/water proves to be the best out of twelve examined oxidation methods.The synthesis is unsuccessful with sterically hindered or oxidizable Grignard reagents.
Epoxides : Part II - Synthesis of Butyrolactones
Moussa, G. E. M.,Basyouni, M. N.,Shaban, M. E.
, p. 800 - 801 (2007/10/02)
1,1-Diarylethylene oxides (Ia-c) react with diethyl malonate in the presence of sodium ethoxide to give γ,γ-diaryl-α-ethoxycarbonyl-γ-butyrolactones (IIa-c) which yield the carboxylactones (IIIa-c) upon alkaline hydrolysis.Decarboxylation of IIIa-c furnishes the corresponding γ,γ-diaryl-γ-butyrolactones (IVa-c).
