270063-54-2 Usage
Uses
Used in Pharmaceutical Research and Development:
BOC-(S)-3-AMINO-4-(3,4-DIFLUORO-PHENYL)-BUTYRIC ACID is utilized as a key building block in the synthesis of pharmaceuticals and drugs. It is instrumental in the development of new therapeutic agents due to its unique chemical properties and potential to contribute to the efficacy of various medications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, BOC-(S)-3-AMINO-4-(3,4-DIFLUORO-PHENYL)-BUTYRIC ACID is employed as a valuable component for the design and synthesis of novel compounds with potential therapeutic applications. Its structure allows for the exploration of new chemical spaces and the discovery of innovative drug candidates.
Used in Drug Synthesis:
BOC-(S)-3-AMINO-4-(3,4-DIFLUORO-PHENYL)-BUTYRIC ACID is used as a precursor in the synthesis of various drugs, contributing to the development of pharmaceuticals with specific therapeutic targets and mechanisms of action. Its presence in the synthesis process can influence the pharmacokinetics, pharmacodynamics, and overall effectiveness of the resulting drug molecules.
Used in Drug Discovery:
BOC-(S)-3-AMINO-4-(3,4-DIFLUORO-PHENYL)-BUTYRIC ACID is leveraged in drug discovery processes to identify and optimize potential drug candidates. Its unique structural features can be exploited to design compounds with improved binding affinities, selectivities, and therapeutic indices, thereby enhancing the chances of discovering effective new medicines.
Check Digit Verification of cas no
The CAS Registry Mumber 270063-54-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,0,0,6 and 3 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 270063-54:
(8*2)+(7*7)+(6*0)+(5*0)+(4*6)+(3*3)+(2*5)+(1*4)=112
112 % 10 = 2
So 270063-54-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H19F2NO4/c1-15(2,3)22-14(21)18-10(8-13(19)20)6-9-4-5-11(16)12(17)7-9/h4-5,7,10H,6,8H2,1-3H3,(H,18,21)(H,19,20)/t10-/m0/s1
270063-54-2Relevant academic research and scientific papers
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
