270065-83-3 Usage
Uses
Used in Pharmaceutical Research:
BOC-(S)-3-AMINO-4-(2-CYANO-PHENYL)-BUTYRIC ACID is used as a reagent for the synthesis of various peptides, contributing to the development of new pharmaceutical compounds. Its protected nature allows for controlled reactions, making it a valuable asset in the synthesis process.
Used in Peptide Synthesis:
In the field of peptide synthesis, BOC-(S)-3-AMINO-4-(2-CYANO-PHENYL)-BUTYRIC ACID is used as a building block to create complex peptide structures. The presence of the cyanophenyl group provides unique properties that can be exploited in the design of therapeutic peptides.
Used in Drug Development:
BOC-(S)-3-AMINO-4-(2-CYANO-PHENYL)-BUTYRIC ACID is used as a key component in the development of new drugs, particularly in the pharmaceutical industry. Its versatility in chemical reactions and the potential for creating novel peptide-based therapeutics make it an important compound in drug discovery and design.
Check Digit Verification of cas no
The CAS Registry Mumber 270065-83-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,0,0,6 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 270065-83:
(8*2)+(7*7)+(6*0)+(5*0)+(4*6)+(3*5)+(2*8)+(1*3)=123
123 % 10 = 3
So 270065-83-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H20N2O4/c1-16(2,3)22-15(21)18-13(9-14(19)20)8-11-6-4-5-7-12(11)10-17/h4-7,13H,8-9H2,1-3H3,(H,18,21)(H,19,20)/t13-/m0/s1
270065-83-3Relevant academic research and scientific papers
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
