270079-48-6

Basic information

• Product Name: N-Methylhistaprodifen dioxalate salt
• Synonyms: N-Methylhistaprodifen dioxalate salt
• CAS NO: 270079-48-6
• Molecular Formula: C25H29N3O8
• Molecular Weight: 499.51306
• Mol File: 270079-48-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 207 °C (decomp)
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Methylhistaprodifen dioxalate salt(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methylhistaprodifen dioxalate salt(270079-48-6)
• EPA Substance Registry System: N-Methylhistaprodifen dioxalate salt(270079-48-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 270079-48-6(Hazardous Substances Data)

Usage

Description

N-Methylhistaprodifen dioxalate salt is a highly active and potent histamine H1-receptor agonist, characterized by its significant potency and selectivity for the histamine H1-receptor. It is more potent than histamine in various tests, including guinea pig ileum and arterial H1-receptor-mediated vasoconstriction, making it the most potent H1-receptor agonist among 17 agonists tested. Importantly, it does not stimulate H2 and H3 histamine receptors, which highlights its potential for specific applications in the study of H1-receptor-mediated physiological and pathophysiological functions.

Uses

Used in Pharmaceutical Research:
N-Methylhistaprodifen dioxalate salt is used as a research compound for studying the role of histamine H1-receptors in various physiological and pathophysiological processes. Its high potency and selectivity make it an ideal tool for investigating the mechanisms of histamine H1-receptor activation and its implications in different diseases and conditions.
Used in Drug Development:
N-Methylhistaprodifen dioxalate salt is used as a lead compound in the development of new drugs targeting histamine H1-receptors. Its potent agonist activity and selectivity for H1-receptors can be leveraged to create more effective and safer medications for treating conditions related to histamine H1-receptor dysregulation.
Used in Preclinical Testing:
N-Methylhistaprodifen dioxalate salt is used as a preclinical testing agent to evaluate the efficacy and safety of potential histamine H1-receptor antagonists or agonists. Its potency and selectivity allow researchers to assess the effectiveness of new compounds in modulating histamine H1-receptor activity and their potential therapeutic applications.
Used in Diagnostic Applications:
N-Methylhistaprodifen dioxalate salt can be used as a diagnostic agent to identify and characterize histamine H1-receptor-mediated responses in various tissues and cell types. Its high potency and selectivity enable accurate assessment of H1-receptor function, which can be valuable in diagnosing conditions related to histamine H1-receptor dysregulation.