270085-89-7Relevant academic research and scientific papers
Studies of precursor-directed biosynthesis with streptomyces, 3. - Structural diversity of 1-O-acyl α-L-rhamnopyranosides by precursor-directed biosynthesis with Streptomyces griseoviridis
Grond, Stephanie,Papastavrou, Ina,Zeeck, Axel
, p. 1875 - 1881 (2007/10/03)
The ability of Streptomyces griseoviridis (strain Tu 3634) to glycosylate various carboxylic acids with 1-rhamnose was investigated by feeding mainly heteroaromatic and aromatic carboxylic acids to growing cultures. The special application of the precursor-directed biosynthesis (PDB) gave rise to a wide variety of acyl α-L-rhamnopyranosides as novel metabolites. The experiments resulted in furanyl, pyrrolyl, thienyl, indolyl, and pyridyl derivatives (1-8), the analogues 9-24 were generated by feeding fluoro-, hydroxy- or aminobenzoic acids or cinnamic acids. All results are discussed with respect to the substrate specificity of the corresponding enzyme system.
