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27013-91-8 Usage


Alpha-Hederin is a triterpenoid saponin that is hederagenin attached to a 2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage. It has been isolated from the stem bark of Kalopanax pictus and is also a saponin found in dry extracts from the leaves of Hedera helix L.


Used in Pharmaceutical Applications:
Alpha-Hederin is used as an inhibitor of β2-adrenergic receptor-GFP fusion proteins for its potential application in the development of drugs targeting adrenergic receptors.
Used in Toxicological Research:
Due to its potential to cause asphyxiation, alpha-Hederin is used in toxicological research to study the effects of saponins on respiratory systems and to develop countermeasures against their toxic effects.

Check Digit Verification of cas no

The CAS Registry Mumber 27013-91-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,0,1 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 27013-91:
88 % 10 = 8
So 27013-91-8 is a valid CAS Registry Number.

27013-91-8 Well-known Company Product Price

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  • Sigma-Aldrich

  • (07512)  α-Hederin  analytical standard

  • 27013-91-8

  • 07512-10MG

  • 3,299.40CNY

  • Detail
  • Sigma-Aldrich

  • (01240585)  α-Hederin  primary pharmaceutical reference standard

  • 27013-91-8

  • 01240585-10MG

  • 9,877.14CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name kalopanaxsaponin A

1.2 Other means of identification

Product number -
Other names taurosidee

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:27013-91-8 SDS

27013-91-8Relevant articles and documents

Antifungal activity of modified hederagenin glycosides from the leaves of Kalopanax pictum var. chinense

Lee, Min-Won,Kim, Sung Uk,Hahn, Dug-Ryoung

, p. 718 - 719 (2001)

Monodesmosides which were obtained from the partial degradation of hederagenin bisdesmosides exhibited significant antifungal effect against Microsporum canis, Coccidioides immitis, Trichophyton mentagrophytes, Cryptococcus neoformans, and Candida albican

Krokhmalyuk et al.

, (1975)

Triterpene glycosides of Dipsacus azureus


, p. 341 - 342 (1998)


Bioactive oleanane-type saponins from the rhizomes of Anemone taipaiensis

Wang, Xiao-Yang,Gao, Hui,Zhang, Wei,Li, Yuan,Cheng, Guang,Sun, Xiao-Li,Tang, Hai-Feng

, p. 5714 - 5720 (2013/10/01)

Investigation of the n-BuOH extract of the rhizomes of Anemone taipaiensis led to the isolation of five new oleanane-type triterpenoid saponins (1-5), together with seven known saponins (6-12). Their structures were determined by the extensive use of 1D and 2D NMR experiments along with ESIMS analyses and acid hydrolysis. The aglycone of 1, 2 and 4 was determined as siaresinolic acid, which was reported in this genus for the first time. The cytotoxicities of the saponins 1-12, prosapogenins 4a, 5a, 10a-12a and sapogenins siaresinolic acid (SA), oleanolic acid (OA), hederagenin (HE) were evaluated against five human cancer cell lines, including HepG2, HL-60, A549, HeLa and U87MG. The monodesmosidic saponins 6-8, 5a, 10a-12a and sapogenins SA, OA, HE exhibited cytotoxic activity toward all cancer cell lines, with IC 50 values ranging from 2.25 to 57.28 μM. Remarkably, the bisdesmosidic saponins 1-4 and 9 showed selective cytotoxicity against the U87MG cells.

Synthesis of α-hederin, δ-hederin, and related triterpenoid saponins

Ple, Karen,Chwalek, Martin,Voutquenne-Nazabadioko, Laurence

, p. 1588 - 1603 (2007/10/03)

The synthesis of α-hederin (3-O-[α-L-rhamnopyranosyl-(1→2) -α-L-arabinopyranosyl]hederagenin, 1), δ-hederin (3-O-(α-L-arabinopyranosyl)hederagenin, 3), and three related triterpenoid saponins is described as part of a study of the structure-activity relationships between triterpenoid saponins and hemolytic activity. 4-Methoxybenzyl α-L-arabinopyranoside (11) was synthesized first and then used to prepare the different arabinose acceptors. Glycosylation between the acceptors and 2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl trichloroacetimidate (20) was performed in excellent yield to give the desired disaccharides. Coupling of the trichloroacetimidate derivatives of the disaccharides to allyl- or methyl-hederagenin gave the protected saponosides in high yields. The saponins and their corresponding methyl esters were then obtained in good to moderate yields after deprotection. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

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