27017-88-5Relevant academic research and scientific papers
Silica gel catalyzed synthesis of quinoxialine 1,4-dioxides under solvent-free conditions using microwave irradiation
Sumiyoshi, Yusuke,Saito, Hiroaki,Miyairi, Shinichi,Takabatake, Tohru
scheme or table, p. 905 - 909 (2009/09/29)
We report on the simple and quick synthesis of quinoxaline 1,4-dioxides in solvent-free conditions under microwave irradiation. Heating of various benzofuroxans and β-ketoesters or 1,3-diketones adsorbed on silica gel in a microwave oven for two minutes affords diverse biologically attractive quinoxaline 1,4-dioxides in high to excellent yields. Silica gel functions not only as support using microwave but also as catalyst and dehydration reagent.
