27025-49-6

Basic information

• Product Name: CARBENICILLIN PHENYL SODIUM
• Synonyms: CARBENICILLIN PHENYL SODIUM;CARFECILLIN;1-phenylester;carbenicillinphenyl;carbenicillinphenylester;6-[(1,3-Dioxo-3-phenoxy-2-phenylpropyl)amino]-3,3-dimethyl-7-oxo-[s-(2,5,6)]4-thia-1-azobycyclo[3,2,0]pentane-2-carbonic acid;6α-[(1,3-Dioxo-3-phenoxy-2-phenylpropyl)amino]penicillanic acid;N-[(2S,5β)-2β-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6α-yl]phenylmalonamidic acid 1-phenyl ester
• CAS NO: 27025-49-6
• Molecular Formula: C₂₃H₂₂N₂O₆S
• Molecular Weight: 476.48
• EINECS: 248-171-2
• Mol File: 27025-49-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 770.9°Cat760mmHg
• Flash Point: 420°C
• Appearance: /
• Density: 1.2538 (rough estimate)
• Vapor Pressure: 5.33E-25mmHg at 25°C
• Refractive Index: 1.6510 (estimate)
• PKA: 2.44±0.50(Predicted)
• CAS DataBase Reference: CARBENICILLIN PHENYL SODIUM(CAS DataBase Reference)
• NIST Chemistry Reference: CARBENICILLIN PHENYL SODIUM(27025-49-6)
• EPA Substance Registry System: CARBENICILLIN PHENYL SODIUM(27025-49-6)

Safety Data

• Hazardous Substances Data: 27025-49-6(Hazardous Substances Data)

Usage

Uses

Antibacterial.

InChI:InChI=1/C23H22N2O6S/c1-23(2)17(21(28)29)25-19(27)16(20(25)32-23)24-18(26)15(13-9-5-3-6-10-13)22(30)31-14-11-7-4-8-12-14/h3-12,15-17,20H,1-2H3,(H,24,26)(H,28,29)/t15?,16-,17+,20-/m1/s1

Upstream product

• 551-16-6 6-Aminopenicillanic Acid 
• 21601-78-5 phenylmalonic acid monophenyl ester 

Relevant articles and documents

Preparation, hydrolysis, and oral absorption of alpha-carboxy esters of carbenicillin.

Twelve alpha-carboxy esters of carbenicillin, a parenteral broad spectrum semisynthetic penicillin, were synthesized and examined as potential oral carbenicillin derivatives. The rates at which the esters were hydrolyzed in vitro to carbenicillin by animal and human tissues were compared and the carbenicillin serum levels arising after oral administration of the esters were measured in squirrel monkeys and human volunteer subjects. The alpha-carboxyphenyl ester of carbenicillin [carfecillin (British Pharmacopoeia approved name), BRL 3475] WAS SELECTED FOR FURTHER STUDY AND IS PRESENTLY UNDERGOING CLInical trial.