270256-21-8

Basic information

• Product Name: 4-azido-1,2-dimethylbenzene
• Synonyms: 4-azido-1,2-dimethylbenzene
• CAS NO: 270256-21-8
• Molecular Weight: 147.18
• Mol File: 270256-21-8.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 4-azido-1,2-dimethylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-azido-1,2-dimethylbenzene(270256-21-8)
• EPA Substance Registry System: 4-azido-1,2-dimethylbenzene(270256-21-8)

Safety Data

• Hazardous Substances Data: 270256-21-8(Hazardous Substances Data)

Upstream product

• 31599-61-8 3,4-dimethyliodobenzene 
• 55499-43-9 3,4-dimethyl phenylboronic acid 
• 99-51-4 4-nitro-o-xylene 
• 95-64-7 4-amino-o-xylene 

Downstream Products

• 1443032-59-4 benzothiazol-2-yl-bis-{[1-(3,4-dimethylphenyl)-1H-[1,2,3]triazol-4-yl]methyl}amine 
• 1562441-58-0 C₂₆H₃₂N₄O₃ 
• 1602732-41-1 C₂₃H₂₁N₅O 
• 1602733-60-7 C₂₃H₂₁N₅O 
• 1258783-15-1 1-(3,4-dimethylphenyl)-4-phenyl-1H-1,2,3-triazole 
• 1309447-85-5 1-(3,4-dimethylphenyl)-7-methyl-5-(4-methylphenyl)-1H-naphtho[1,2-d][1,2,3]triazole 
• 1309447-84-4 1-(3,4-dimethylphenyl)-5-phenyl-1H-naphtho[1,2-d][1,2,3]triazole 
• 1258783-19-5 1-(3,4-dimethylphenyl)-4,5-diphenyl-1H-1,2,3-triazole 
• 1169853-40-0 C₃₀H₂₄N₄O 
• 1169852-86-1 C₂₃H₁₈N₄O₂ 
• 1169853-22-8 C₃₄H₃₃N₄O⁽¹⁺⁾*Cl^(1-) 
• 1169852-64-5 C₂₇H₂₆N₄O₂ 
• 1169853-04-6 C₃₀H₂₃N₃O₂ 
• 1169852-38-3 C₂₄H₁₉N₃O₃ 

Relevant articles and documents

Synthesis and antitumor activity of 1-substituted 1,2,3-triazole-mollugin derivatives

A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.

Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II

Aminopeptidase N (APN) has been proved to be deeply associated with cancer angiogenesis, metastasis and invasion. Therefore, APN gains increasing attention as a promising anti-tumor target. In the current study, we report the design, synthesis, biological evaluation and structure-activity relationship of one new series of leucine ureido derivatives containing the 1,2,3-triazole moiety. Among them, compound 31f was identified as the best APN inhibitor with IC50 value being two orders of magnitude lower than that of the positive control bestatin. Compound 31f possessed selective cytotoxicity to several tumor cell lines over the normal cell line human umbilical vein endothelial cells (HUVECs). Notably, when combined with 5-fluorouracil (5-Fu), 31f exhibited synergistic anti-proliferation effect against several tumor cell lines. At the same concentration, 31f exhibited much better anti-angiogenesis activities than bestatin in the HUVECs capillary tube formation assay and the rat thoracic aorta rings test. In the in vitro anti-invasion assay, 31f also exhibited superior potency over bestatin. Moreover, considerable in vivo antitumor potencies of 31f alone or in combination with 5-Fu were observed without significant toxic signs in a mouse heptoma H22 tumor transplant model.

DBU-promoted Cu(OAc)2·H2O-catalysed coupling reactions of aryl iodides and sodium azide

An efficient and simple protocol for the synthesis of aryl azides by the coupling of aryl iodides with sodium azide, in good to excellent yields in DMSO at 95°C under catalysis by Cu(OAc)2·H2O and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), has been established. The optimised loadings of Cu(OAc)2·H2O and DBU were 10 mol% and 15 mol% respectively.