270263-02-0Relevant academic research and scientific papers
Homoallylglycine residues are superior precursors to orthogonally modified thioether containing polypeptides
Perlin, Pesach,Gharakhanian, Eric G.,Deming, Timothy J.
, p. 6196 - 6199 (2018/06/18)
Homoallylglycine N-carboxyanhydride, Hag NCA, monomers were synthesized and used to prepare polypeptides containing Hag segments with controllable lengths of up to 245 repeats. Poly(l-homoallylglycine), GHA, was found to adopt an α-helical conf
Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis
Brown, Neil,Xie, Baohan,Markina, Nataliya,VanderVelde, David,Perchellet, Jean-Pierre H.,Perchellet, Elisabeth M.,Crow, Kyle R.,Buszek, Keith R.
scheme or table, p. 4876 - 4879 (2009/05/30)
We have prepared a novel speculative eight-membered lactam demonstration library based on the skeletal structure of the potent antitumor marine natural product octalactin A. The basic scaffold was readily constructed in a convergent fashion via ring-closing metathesis chemistry from the corresponding diene amides. A cursory examination of the biological properties of the library validates the relevance and significance of these structures.
AN ENANTIOSELECTIVE ROUTE TO AN INTERMEDIATE OF THE CARBAPENAM SYSTEM FROM THE CHIRAL γ-BUTYROLACTONE
Takano, Seiichi,Kasahara, Chiyoshi,Ogasawara, Kunio
, p. 631 - 634 (2007/10/02)
A new enantioselective synthesis of the keto ester(16) containing β-lactam ring system has been developed using the chiral lactone(1) as a starting material.
