27063-98-5

Usage

Uses

Used in Pharmaceutical Research and Development:
3-Bromo-4,5-dimethylpyridine is utilized as a building block in the synthesis of various pharmaceuticals. Its ability to participate in cross-coupling reactions makes it an essential component in the creation of complex molecular structures with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 3-Bromo-4,5-dimethylpyridine is employed as a key intermediate for the synthesis of compounds with pesticidal properties. Its reactivity and stability contribute to the development of effective and environmentally friendly agrochemicals.
Used in Organic Synthesis:
3-Bromo-4,5-dimethylpyridine is used as a versatile intermediate in organic synthesis for the production of a wide range of organic compounds. Its chemical properties allow for the formation of various functional groups and the construction of complex molecular frameworks, which are vital in the synthesis of specialty chemicals and materials.

InChI:InChI=1/C7H8BrN/c1-5-3-9-4-7(8)6(5)2/h3-4H,1-2H3

Upstream product

• 583-58-4 3,4-Lutidin 

Downstream Products

• 203569-15-7 3-bromo-4-formyl-5-methylpyridine 
• 51454-50-3 3-bromo-5-methyl-pyridine-4-carbonitrile 

Relevant academic research and scientific papers

A short synthesis of the plant alkaloid 4-methyl-2,6-naphthyridine

A new synthesis of the 2,6-naphthyridine alkaloid 4-methyl-2,6-naphthyridine from Antir-rhinum majus has been developed. Key steps are a regioselective oxidation of 3-bromo-4,5-dimethylpyridine to the corresponding 4-formyl derivative, and the annulation of the second pyridine ring by Suzuki-Miyaura cross-coupling using (E)-2-ethoxyvinylboronic acid pinacol ester as a masked acetaldehyde equivalent. This protocol gives the alkaloid in four steps starting from commercially available 3,4-dimethylpyridine in 15% overall yield. This annulation protocol should be useful for the synthesis of other condensed pyridines as well.

HETEROCYCLIC COMPOUNDS AS EP4 RECEPTOR ANTAGONISTS

The present invention provides a compound represented by the formula (1): wherein each symbol is as defined in the specification or a salt thereof has an EP4 receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of EP4 receptor associated diseases (e.g., rheumatoid arthritis, aortic aneurysm, endometriosis, ankylosing spondylitis, inflammatory breast cancer etc.) and the like.

ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

CYANOPYRIDINE PESTICIDES

The present invention relates to cyanopyridine compounds of the general formula (I) and to the agriculturally useful salts thereof and to compositions comprising such compounds. The invention also relates to the use of the cyanopyridine compounds, of their salts or of compositions comprising them for combating animal pests. In formula (I) n is 0, 1 or 2; X is N, N-O or C-R4; Y is N, N-O or C-R5; Z is N, N-O or C-R6; with the proviso that one of the variables X, Y and Z is N or NO and the other two variables are optionally substituted carbon atoms; R1, R2 are, independently of one another, selected from the group consisting of hydrogen, C(=O)-R7, optionally subsitutetd C1-C10-alkyl, C2-C6-alkenyl, C2-C10-alkinyl, C1-C10-alkoxy or C3-C10-cycloalkyl, or R1 and R2 together with the adjacent nitrogen form a 3 to 10-membered ring, optionally substituted by 1, 2 or 3 radicals selected from C1-C5-alkyl and halogen, wherein the ring may contain, in addition to the nitrogen and carbon ring members, 1, 2 or 3 heteroatoms as ring members selected from the group consisting of nitrogen, oxygen, sulfur, a group SO, SO2 or N-R8; R3 is hydrogen, nitro, cyano, azido, amino, halogen, sulfonylamino, sulfenylamino, sulfinylamino, C(=O)R9, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C8- cycloalkyl, C1-C6-alkoxy, C1-C6-alkylthio, (C1-C6-alkyl)amino, di(C1-C6-alkyl)amino, C1-C6-alkylsulfinyl, or C1-C6-alkylsulfonyl, R4, R5 and R6 are independently of one another selected from the group consisting of hydrogen, halogen, cyano, azido, nitro, C1-C6-alkyl, C3-C8-cycloalkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, C1-C4-haloalkoxy, C1-C4-haloalkylthio, C2-C6-alkenyl, C2-C6-alkinyl, (C1-C4-alkoxy)carbonyl, amino, (C1-C4-alkyl)amino, di(C1-C4-alkyl)amino, aminocarbonyl, (C1-C4-alkyl)aminocarbonyl, di(C1-C4-alkyl)aminocarbonyl, hydroxysulfonyl, sulfonylamino, sulfenylamino, sulfinylamino and C(=O)-R10.

ISOTHIAZOLOPYRIDIN-3-YLENAMINES FOR COMBATING ANIMAL PESTS

The present invention relates to lsothiazolopyridin-3-ylenamine compounds of the general formula I and to the agriculturally useful salts thereof and to compositions comprising such compounds. The invention also relates to the use of the lsothiazolopyridin-3-ylenamine compounds, of their salts or of compositions comprising them for combating animal pests. A lsothiazolopyridin-3-ylenamine compound of the present invention is represented by the following formula I:

A short synthesis of (±)-actinidine

The monoterpene alkaloid (±)-actinidine 10 is prepared in 5 steps from 3,4-dimethylpyridine using a pyridine radical cyclisation for the formation of the cyclopentano[c]pyridine skeleton.