270902-71-1

Upstream product

• 6605-22-7 3,5:6,7-bis-O-(1-methylethylidene)-α-D-glucoheptonic γ-lactone 
• 2219-28-5 (R)-5-hydroxy-L-lysine dihydrochloride hydrate 
• 89-67-8 α-D-glucoheptonic γ-lactone 
• 374602-79-6 (3S,6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one*HCl 
• 270902-67-5 8,8-dimethyl-2-O-methyl-3,5-O-(1-methylethylidene)-6,7,8,9-tetradeoxy-D-gluo-6-nonenonic acid (6E)-γ-lactone 
• 270902-65-3 (4R,4aS,7R,7aR)-4-((R)-1,2-dihydroxyethyl)-7-methoxy-2,2-dimethyltetra-hydro-6H-furo[3,2-d][1,3]dioxin-6-one 
• 136289-11-7 (4R,4aS,7R,7aR)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-7-methoxy-2,2-dimethyl-tetrahydro-6H-furo[3,2-d][1,3]dioxin-6-one 
• 270902-69-7 (3S,6R)-3-(tert-butoxycarbonyl)aminohexahydro-6-(cyclohexanecarbonyl)-oxy-2H-azepin-2-one 
• 270902-66-4 (4S,4aR,7R,7aR)-7-methoxy-2,2-dimethyl-6-oxotetrahydro-4H-furo[3,2-d][1,3]dioxine-4-carbaldehyde 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 2443-89-2 1,1-Diiodo-2,2-dimethylpropane 
• 270902-70-0 (3S, 6R)-3-aminohexahydro-6-(cyclohexanecarbonyl)oxy-2H-azepin-2-one 

Downstream Products

• 270902-51-7 (2R,3R,4S,5R,6E)-3,4,5-trihydroxy-2-methoxy-8,8-dimethyl-N-[(3S,6R)-hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl]non-6-enamide 

Relevant academic research and scientific papers

CERTAIN SUBSTITUTED CAPROLACTAMS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN TREATING TUMORS

The present invention relates to certain substituted caprolactam compounds of formula (I), where R1 is (C1-6)alkyl or (C3-6)cycloalkyl; R2 is hydrogen or (C1-6)alkyl; X is (C1-12)alkylene; (C2-12)alkenylene; or (C2-12)alkynylene; m is 0 or 1; and R3 is (C

An Expedient Synthesis of LAF389, a Bengamide B Analogue

An optimized, convergent, safe synthesis of LAF389 (9), an anticancer agent analogous to bengamide B, is described. Starting from α-D- glucoheptonic (D-glycero-D-gulo-heptonic acid) γ-lactone (10), the lactone 15 was constructed in five steps. Major impro

Synthesis and antitumor activity of ester-modified analogues of bengamide B

Bengamide B, a novel sponge-derived marine natural product with broad spectrum antitumor activity, was not suitable for further preclinical development because of its difficult synthesis and very poor water solubility. Bengamide B produced a 31% T/C at it