270902-71-1Relevant articles and documents
CERTAIN SUBSTITUTED CAPROLACTAMS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN TREATING TUMORS
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Page 14, (2010/11/30)
The present invention relates to certain substituted caprolactam compounds of formula (I), where R1 is (C1-6)alkyl or (C3-6)cycloalkyl; R2 is hydrogen or (C1-6)alkyl; X is (C1-12)alkylene; (C2-12)alkenylene; or (C2-12)alkynylene; m is 0 or 1; and R3 is (C
Synthesis and antitumor activity of ester-modified analogues of bengamide B
Kinder Jr.,Versace,Bair,Bontempo,Cesarz,Chen,Crews,Czuchta,Jagoe,Mou,Nemzek,Phillips,Tran,Wang,Weltchek,Zabludoff
, p. 3692 - 3699 (2007/10/03)
Bengamide B, a novel sponge-derived marine natural product with broad spectrum antitumor activity, was not suitable for further preclinical development because of its difficult synthesis and very poor water solubility. Bengamide B produced a 31% T/C at it