270929-36-7Relevant academic research and scientific papers
Efficient and regioselective 4-amino-de-chlorination of 2,4,6- trichloropyrimidine with N-sodium carbamates
Zanda, Matteo,Talaga, Patrice,Wagner, Alain,Mioskowski, Charles
, p. 1757 - 1761 (2000)
4-N-Alkoxycarbonyl-2,6-dichloropyrimidines have been synthesized with good to excellent regioselectivity and yields from 2,4,6-trichloropyrimidine and N-sodium carbamates in DMF, at room temperature, in 15-30 minutes. (C) 2000 Elsevier Science Ltd.
Regioselective 4-amino-de-chlorination of trichloro- and dichloro-pyrimidines with N-sodium carbamates
Montebugnoli, Dario,Bravo, Pierfrancesco,Corradi, Eleonora,Dettori, Giovanna,Mioskowski, Charles,Volonterio, Alessandro,Wagner, Alain,Zanda, Matteo
, p. 2147 - 2153 (2007/10/03)
4-N-Alkoxycarbonylamino-2,6-dichloro- and -2-chloro-pyrimidines have been synthesized in good to excellent regioselectivity and yields from N-sodium carbamates and, respectively, 2,4,6-trichloropyrimidine and 2,4-dichloropyrimidine, in DMF, rt, 15-30 min. The reaction is effective also with 4,6-dichloropyrimidine, producing 4-N-alkoxycarbonylamino-6-chloropyrimidines in good yields. Some conformational features of 4-N-alkoxycarbonylamino-2,6-dichloro-pyrimidines have been investigated by X-ray diffraction and 1H NMR spectroscopy.
