27093-47-6

Upstream product

• 2999-46-4 Ethyl isocyanoacetate 

Downstream Products

• 131194-80-4 ethyl 4-(benzyloxycarbonyl)-5-(acetoxymethyl)pyrrole-2-carboxylate 
• 131194-86-0 5-[4-((1R,5S,6R)-6-Benzyloxycarbonyl-1-ethoxycarbonyl-4-oxo-2,3-diphenyl-bicyclo[3.1.0]hex-2-en-6-yl)-1-methyl-1H-imidazol-2-yl]-1H-pyrrole-2,4-dicarboxylic acid 4-benzyl ester 2-ethyl ester 
• 131194-78-0 C₃₃H₃₁N₃O₈ 
• 131194-79-1 5-(ethoxycarbonyl)-3-(benzyloxycarbonyl)-2-formylpyrrole 
• 131194-81-5 ethyl 4-(benzyloxycarbonyl)-5-(hydroxymethyl)pyrrole-2-carboxylate 

Relevant academic research and scientific papers

Silver-Catalyzed Cascade Reaction of β-Enaminones and Isocyanoacetates to Construct Functionalized Pyrroles

An unexpected silver-catalyzed cascade reaction of β-enaminones and isocyanoacetates affording functionalized pyrrole derivatives is reported. In this reaction, tautomeric equilibria of β-enaminones are utilized to generate imine partners in situ. A hypothesized sequential Mannich addition/cyclization of imine tautomers and isocyanoacetates followed by an unprecedented ring-opening of the resultant 2-imidazolines and dehydration-condensation deliver the final 1,2,4,5-tetrasubstituted pyrrole products.