2712-92-7

Upstream product

• 53117-00-3 bis(diethylamino)trifluoromethylphosphine 
• 65748-24-5 1-bromo-1,1,2-trifluoro-2-iodo-ethane 
• 393-02-2 Tetrakis(trifluoromethyl)cyclotetraphosphane 
• 421-59-0 trifluoromethyldiiodophosphine 
• 1112-04-5 trifluoromethyldifluorophosphine 
• 58310-39-7 trifluoromethyliodophosphine 

Relevant academic research and scientific papers

CF3-P(NEt2)2 ALS SCHLUESSELSUBSTANZ FUER CF3-SUBSTITUIERTE PHOSPHANE - DIREKTSYNTHESE UND VERWENDUNG

For the first time CF3-P(NEt2)2 is easily available by the three component reaction of P(NEt2)3/PCl3/CF3Br.The advantages of the title compound as educt for phosphanes containing one CF3-group are pointed out.

TRIFLUOROMETHYLPHOSPHINYL BIS-TRIAZOLIDES IN THE SYNTHESIS OF TRIFLUOROMETHYLPHOSPHONATE ANALOGUES OF NUCLEOTIDES

The bis-triazolide of trifluoromethylphosphinic acid is prepared from trifluoromethylphosphorous dibromide, CF3PBr2, and reacted in situ with alcohols.The resulting triazolomonoesters are efficiently hydrolysed and oxidised to give trifluoromethylphosphonate monoesters, as shown for the nucleotide analogues adenosine 5'-O-trifluoromethylphosphonate and thymidine 3'-O-trifluoromethylphosphonate, novel nucleoside esters having a trifluoromethylphosphoryl function.