27127-44-2Relevant academic research and scientific papers
Cytotoxic 4-phenylcoumarins from the leaves of Marila pluricostata
Lopez-Perez, Jose L.,Olmedo, Dionisio A.,Del Olmo, Esther,Vasquez, Yelkaira,Solis, Pablo N.,Gupta, Mahabir P.,San Feliciano, Arturo
, p. 369 - 373 (2005)
Bioassay-guided fractionation of the CH2Cl2 extract of the leaves of Marila pluricostata led to the isolation of 17 naturally occurring 4-phenylcoumarins, three of them, 5-hydroxy-8,8-dimethyl-4-phenyl-9, 10-dihydro-8H-pyrano-[2,3-f]chromen-2-one(1),5-hydroxy-8,8-dimethyl-4-phenyl-6- propionyl-9,10-dihydro-8H-pyrano-[2,3-f]chromen-2-one (2), and 5,7-dihydroxy-8-(3-methylbut-2-enyl)-4-phenylchromen-2-one (3), are new natural compounds; the remaining (4-17) are known mammea-type coumarins. Their structures were established by spectroscopic means. All compounds were tested in cytotoxicity assays against the MCF-7, II-460, and SF-268 human cancer cell lines.
