2714-91-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Fluoro-2-phenylbenzoic acid is used as a building block for the synthesis of various pharmaceuticals due to its ability to enhance the bioavailability and pharmacokinetic properties of drugs. Its fluoro-substituted structure allows for improved drug delivery and efficacy.
Used in Agrochemical Industry:
4-Fluoro-2-phenylbenzoic acid is also used as a building block in the synthesis of agrochemicals, contributing to the development of more effective and targeted pesticides and other agricultural products.
Used in Medicinal Chemistry Research:
4-Fluoro-2-phenylbenzoic acid is used as a research compound for studying its potential anti-cancer and anti-inflammatory properties. Its unique structure allows scientists to explore its therapeutic potential and develop new drugs for various diseases.
Used in Drug Discovery and Development:
4-Fluoro-2-phenzoic acid is utilized in drug discovery and development processes, where its versatile chemical properties and potential therapeutic effects make it a valuable asset in creating new and improved medications.

Upstream product

• 1841-43-6 4-fluoro-2-phenylbenzonitrile 
• 724-10-7 4-Fluoro-2-phenyl benzoic acid methyl ester 
• 653-92-9 methyl 2-bromo-4-fluorobenzoate 
• 98-80-6 phenylboronic acid 
• 1261678-05-0 methyl 2-iodo-4-fluorobenzoate 
• 860594-92-9 5-nitro-biphenyl-2-carbonitrile 
• 91822-42-3 5-amino-[1,1‘-biphenyl]-2-carbonitrile 
• 591-50-4 iodobenzene 

Downstream Products

• 1514-15-4 3-fluoro-9-fluorenone 

Relevant academic research and scientific papers

Palladium-catalyzed intramolecular aromatic C-H acylation of 2-arylbenzoyl fluorides

The catalytic intramolecular cyclization of acyl fluorides using a Pd(OAc)2/PCy3 system is described. A wide range of 2-arylbenzoyl fluoride derivatives can be used as fluorenone precursors and the reaction proceeds via an intramolecular coupling between aromatic C-H bonds with acyl C-F bonds. The reaction can be applied to the synthesis of indenofluorenedione derivatives and to the construction of other molecules with fivemembered rings.

Synthesis and Biological Activity of Novel Succinate Dehydrogenase Inhibitor Derivatives as Potent Fungicide Candidates

In searching for novel fungicidal leads, the novel bioactive succinate dehydrogenase inhibitor (SDHI) derivatives were designed and synthesized by the inversion of carbonyl and amide groups. Bioassay indicated that compound 5i stood out with a broad spectrum of in vitro activity against five fungi. Its EC50 value (0.73 μg/mL) was comparable to that of boscalid (EC50 of 0.51 μg/mL) and fluxapyroxad (EC50 of 0.19 μg/mL) against Sclerotinia sclerotiorum. For Rhizoctonia cerealis, 5i and 5p with EC50 values of 4.61 and 6.48 μg/mL, respectively, showed significantly higher activity than fluxapyroxad with the EC50 value of 16.99 μg/mL. In vivo fungicidal activity of 5i exhibited an excellent inhibitory rate (100%) against Puccinia sorghi at 50 μg/mL, while the positive control boscalid showed only a 70% inhibitory rate. Moreover, 5i showed promising fungicidal activity with a 60% inhibitory rate against Rhizoctonia solani at 1 μg/mL, which was better than that of boscalid (30%). Compound 5i possessed better in vivo efficacy against P. sorghi and R. solani than boscalid. Molecular docking showed that even the carbonyl oxygen atom of 5i was far from the pyrazole ring. It could also form hydrogen bonds toward the hydroxyl hydrogen and amino hydrogen of TYR58 and TRP173 on SDH, respectively, which consisted of the positive control fluxapyroxad. Fluorescence quenching analysis and SDH enzymatic inhibition studies also validated its mode of action. Our studies showed that 5i was worthy of further investigation as a promising fungicide candidate.