27147-97-3Relevant academic research and scientific papers
Rhodium-catalyzed coupling of α-lactams with indole derivatives
Box, Hannah K.,Upul Kumarasinghe,Nareddy, Radhika R.,Akurathi, Gopalakrishna,Chakraborty, Amarraj,Raji, Babatunde,Rowland, Gerald B.
, p. 9709 - 9717 (2015/02/02)
We report herein a method that allows for the formation of a C-N bond between the C-3 carbon of α-lactams and the nitrogen atom of indoles. A general procedure for the coupling of indoles and α-lactams in only 25 min with high yield is reported. The scope of the reaction was extended by the development of a method for the in situ generation of less stable phenyl-substituted α-lactams. The developed method provides an atom-economical method for the formation of substituted α-amino amides that are found in a variety of biologically-active compounds.
