271576-80-8

Basic information

• Product Name: 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole
• Synonyms: 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole;SD-06;SD-06-1
• CAS NO: 271576-80-8
• Molecular Formula: C₂₀H₂₀ClN₅O₂
• Molecular Weight: 397.8581
• Product Categories: MAPK
• Mol File: 271576-80-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 652.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.367
• Storage Temp.: 2-8°C
• PKA: 9.39±0.50(Predicted)
• CAS DataBase Reference: 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole(271576-80-8)
• EPA Substance Registry System: 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole(271576-80-8)

Safety Data

• Hazardous Substances Data: 271576-80-8(Hazardous Substances Data)

Usage

General Description

The chemical "3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole" is a complex compound containing a pyrazole core with additional functional groups attached. It consists of a piperidyl group, a pyrimidinyl group, a chlorophenyl group, and a 2-hydroxyacetyl group. This chemical structure suggests potential biological activity, as pyrazoles have been found to exhibit a wide range of pharmacological properties, including antiproliferative and anti-inflammatory effects. The presence of a piperidyl group may indicate central nervous system activity, while the chlorophenyl group could contribute to interactions with various receptors. The hydroxyacetyl group contains a hydroxyl functional group which may influence solubility and bioavailability. Overall, this compound's unique structure makes it a potential candidate for further investigation in medicinal chemistry and drug development.

Upstream product

• 271576-76-2 4-[3-(4-chlorophenyl)-4-piperidin-4-yl-1H-pyrazol-5-yl]pyrimidine 
• 1113-60-6 3-hydroxy-2-oxopropionic acid 
• 7397-62-8 butyl glycolate 

Downstream Products

• 635725-11-0 sodium 2-{4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl}-2-oxoethyl hydrogen phosphate 
• 635725-10-9 2-{4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl}-2-oxoethyl dihydrogen phosphate 
• 635725-13-2 2-{4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl}-2-oxoethyl N,N-dimethylglycinate hydrochloride 

Relevant articles and documents

Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase

Starting from an initial HTS screening lead, a novel series of C(5)-substituted diaryl pyrazoles were developed that showed potent inhibition of p38α kinase. Key to this outcome was the switch from a pyridyl to pyrimidine at the C(4)-position leading to analogs that were potent in human whole blood based cell assay as well as in a number of animal efficacy models for rheumatoid arthritis. Ultimately, we identified a clinical candidate from this substrate; SD-0006.