271577-52-7Relevant academic research and scientific papers
Synthesis and antifibrillatory activity of nibentan and its analogues
Davydova, Nadejda K.,Sizova, Olga S.,Vinogradova, Svetlana M.,L'Vov, Alexandre I.,Glushkov, Robert G.,Yuzhakov, Sergey D.,Mashkovskiy, Michail D.
, p. 205 - 215 (2007/10/03)
A series of 1,5-diaminopentane derivatives, structurally related to nibentan, was synthesized and tested for antifibrillatory activity. Improved modifications of some known chemical syntheses were proposed. (±)-N-[5- (Diethylamino)-1-(4-nitrophenyl)pentyl]-benzamide hydrochloride, (±)-N-[5- (diethylamino)-1-(4-nitrophenyl)pentyl]-4-nitrobenzamide hydrochloride and (±)-N-[5-(diethylamino)-1-(4-hydroxyphenyl)pentyl]-4-nitrobenzamide hydrochloride were more potent than nibentan and possessed a longer duration of action (up to 5 h in comparison with 60-90 min for nibentan). The antifibrillatory activity of (±)-N-[5-(diethylamino)-1-(4- methoxyphenyl)pentyl]-4-nitrobenzamide hydrochloride was comparable to that of nibentan but exceeded the potency of D-sotalol and sematilide. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
