271586-14-2Relevant academic research and scientific papers
Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities
Jew, Sang-Sup,Kim, Eun-Kyung,Je, Sun-Mi,Zhao, Long-Xuan,Kim, Hyung-Ook,Park, Hyeung-Geun,Ko, Kwang-Ho,Kim, Won-Ki,Kim, Hwa-Jung,Cheong, Jae Hoon,Lee, Eung-Seok
, p. 1087 - 1103 (2007/10/03)
A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir (3).
