271597-49-0Relevant academic research and scientific papers
Disoxaril-related 3-(diethylamino)-5-phenylisoxazoles
Mazzei, Mauro,Dondero, Ramona,Ledda, Bernardetta,Demontis, Francesca,Vargiu, Laura
, p. 119 - 124 (2007/10/03)
Previous research has shown that 3-(dialkylamino)-5-phenylisoxazoles possessing a compact structure were active against HRV-2 and, consequently, presented a type B activity. In this paper, 3-(diethylamino)-5-phenylisoxazoles, which are structurally more elongated and related to Disoxaril, were synthesized in view to attempt type A activity against HRV-14. Unfortunately, all tested compounds were devoid of activity against HRV-14 (and HIV-1) or exhibited great toxicity. Copyright (C) 2000 Elsevier Science S.A.
