271597-73-0

Basic information

• Product Name: 2-Propyn-1-one, 1-(2-thiazolyl)-
• Synonyms: 2-Propyn-1-one, 1-(2-thiazolyl)-
• CAS NO: 271597-73-0
• Molecular Formula: C₆H₃NOS
• Molecular Weight: 137.16
• Mol File: 271597-73-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 245.6±23.0 °C(Predicted)
• Appearance: /
• Density: 1.319±0.06 g/cm3(Predicted)
• PKA: -0.71±0.10(Predicted)
• CAS DataBase Reference: 2-Propyn-1-one, 1-(2-thiazolyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-one, 1-(2-thiazolyl)-(271597-73-0)
• EPA Substance Registry System: 2-Propyn-1-one, 1-(2-thiazolyl)-(271597-73-0)

Safety Data

• Hazardous Substances Data: 271597-73-0(Hazardous Substances Data)

Upstream product

• 271597-72-9 1-(thiazol-2-yl)prop-2-yn-1-ol 

Relevant articles and documents

Phosphonium-Ring-Fused Bicyclic Metallafuran Complexes of Ruthenium and Osmium

Metallafuran complexes with a fused five-membered phosphonium ring were synthesized from reactions between terminal ynones HC≡C(C=O)R and cis-[Ru/Os(dppm)2Cl2] (dppm=1,1-bis(diphenylphosphino)methane). A metal–vinylidene-involving pathway was found to be an energetically feasible formation mechanism for these complexes. These phosphonium-containing metallafurans, like many phosphonium-functionalized drugs, have the ability to induce mitochondrial dysfunction. They also exhibit stronger cytotoxicity against several human cancer cell lines in comparison with their metal precursors and the classic anticancer drug cisplatin. Overall, this work provides structural and mechanistic insights for the rational design of functional metallacycles via activation of alkynes by RuII and OsII centers.