271601-01-5Relevant academic research and scientific papers
2,4-Disubstituted thiazoles by regioselective cross-coupling or bromine-magnesium exchange reactions of 2,4-dibromothiazole
Gross, Stefan,Heuser, Stefan,Ammer, Carolin,Heckmann, Golo,Bach, Thorsten
experimental part, p. 199 - 206 (2011/03/18)
Cross-coupling reactions occur on 2,4-dibromothiazole preferentially at the more electron-deficient 2-position. This fact can be favorably used to prepare 2-substituted 4-bromothiazoles, which serve as precursors for 2,4-disubstituted thiazoles. Protocols
Synthesis of 2-(o-hydroxyaryl)-4-arylthiazoles by regioselective Pd(0)- catalyzed cross-coupling
Bach, Thorsten,Heuser, Stefan
, p. 1707 - 1710 (2007/10/03)
The difunctional substrate 2,4-dibromothiazole 2 was transformed into the title compounds 1 by consecutive Pd(0)-catalyzed cross-coupling reactions. Aryl zinc reagents which were prepared by ortho-lithiation of compounds 3 and subsequent transmetalation w
