27185-57-5

Upstream product

• 49633-28-5 1,2-bis-(p-methylphenylsulfonamido)-benzene 
• 98-59-9 p-toluenesulfonyl chloride 
• 99-56-9 4-Nitrophenylene-1,2-diamine 

Downstream Products

• 70376-36-2 5-nitro-1,3-bis-(toluene-4-sulfonyl)-1,3-dihydro-benzo[1,2,5]thiadiazole 2-oxide 

Relevant academic research and scientific papers

Pd(II)-Catalyzed Aerobic Intermolecular 1,2-Diamination of Conjugated Dienes: A Regio- and Chemoselective [4 + 2] Annulation for the Synthesis of Tetrahydroquinoxalines

A Pd(II)-catalyzed aerobic intermolecular 1,2-diamination of conjugated dienes was developed for the regio- and chemoselective preparation of a variety of functionalized tetrahydroquinoxalines, using simple sulfonyl protected o-phenylendiamines as a nitrogen source. This methodology provides a direct and efficient synthesis of tetrahydroquinoxalines. O2 was used as the stoichiometric oxidant, and reaction conditions were applied to a series of o-phenylendiamines and conjugated dienes. 35 examples are described, and good yields and selectivities are obtained for the majority of the products.

ENZYME INHIBITORS

The present subject matter relates generally to compounds having the formula (I): wherein each of X, Y, R1, R2, R3, R4, and n are as defined herein. Compounds of formula (I) may act as inhibitors of the thioredoxin reductase enzyme system. The subject matter also relates to use, formulation and preparation of the compounds. The compounds may be useful in the treatment of inflammatory and oxidative diseases and conditions. The compounds may also provide useful anti-proliferative and anti- apoptotic effects.