27199-40-2 Usage
General Description
Pifexole is a synthetic chemical compound that belongs to the class of drugs known as dopamine agonists. It is primarily used for the treatment of Parkinson's disease and other neurological conditions by increasing the levels of dopamine in the brain. Pifexole works by stimulating the dopamine receptors, which helps to improve motor function and reduce the symptoms of tremors, rigidity, and slow movements associated with these conditions. It has also been studied for its potential use in the treatment of depression and other psychiatric disorders due to its effects on the brain's neurotransmitter system. Pifexole is typically administered orally and is generally well-tolerated, although it may cause side effects such as nausea, dizziness, and hallucinations in some individuals. It is important to use this medication under the guidance and supervision of a healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 27199-40-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,1,9 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 27199-40:
(7*2)+(6*7)+(5*1)+(4*9)+(3*9)+(2*4)+(1*0)=132
132 % 10 = 2
So 27199-40-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H8ClN3O/c14-11-4-2-1-3-10(11)13-16-12(17-18-13)9-5-7-15-8-6-9/h1-8H
27199-40-2Relevant articles and documents
Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles
Tolmachev, Andrey,Bogolubsky, Andrey V.,Pipko, Sergey E.,Grishchenko, Alexander V.,Ushakov, Dmytro V.,Zhemera, Anton V.,Viniychuk, Oleksandr O.,Konovets, Anzhelika I.,Zaporozhets, Olga A.,Mykhailiuk, Pavel K.,Moroz, Yurii S.
, p. 616 - 624 (2016/10/21)
One-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and nitriles was optimized to parallel chemistry. The method was validated on a 141 member library; the desired products were recovered with a high success rate and in moderate yields. Practical application of the approach was demonstrated in the synthesis of bioactive compound pifexole and agonists of free fatty acid receptor 1. A library of 4 948 100 synthesizable drug-like 3,5-disubstituted 1,2,4-oxadiazoles was enumerated based on the method and available validated reagents.
