27200-69-7Relevant academic research and scientific papers
Identification of benzofused five-membered sultams, potent dual NOD1/NOD2 antagonists in vitro and in vivo
Ma, Yao,Li, Xueyuan,Pei, Yameng,Ye, Jingjia,Wei, Xiduan,Yang, Jingshu,Si, Guangxu,Tian, Jingyuan,Dong, Yi,Liu, Gang
, (2020/07/31)
Nucleotide-binding oligomerization domain-containing proteins 1 and 2 play important roles in immune system activation. Recently, a shift has occurred due to the emerging knowledge that preventing nucleotide-binding oligomerization domains (NODs) signalin
Rhodium(iii)-catalyzed sulfonamide directed ortho C-H carbenoid functionalization via metal carbene migratory insertion
Dong, Yi,Chen, Jiajing,Xu, Heng
supporting information, p. 2027 - 2030 (2019/02/19)
A rhodium(iii)-catalyzed sulfonamide directed ortho C-H carbenoid functionalization has been developed with good yields. This method is attractive due to its broad substrate scope, and enables derivation of diverse biologically active sulfonamide structures and late-stage modification of sulfa drugs.
Rhodium-catalyzed direct C-H bond alkynylation of aryl sulfonamides with bromoalkynes
Hou, Hongcen,Zhao, Yongli,Pu, Shouzhi,Chen, Junmin
supporting information, p. 2948 - 2953 (2019/03/21)
Herein we report a novel rhodium-catalyzed ortho-mono-alkynylation of aryl sulfonamides. The reactions of N-tosylacetamides with triisopropylsilyl (TIPS)-substituted bromoalkyne are catalyzed by a [(Cp?RhCl2)2] complex without cyclization, forming ortho-(
Iridium-Catalyzed ortho-C?H Amidation of Benzenesulfonamides with Sulfonyl Azides
Hou, Hongcen,Zhao, Yongli,Sheng, Shouri,Chen, Junmin
supporting information, p. 4393 - 4398 (2019/08/28)
We developed herein an iridium-catalyzed direct C?H activation/ C?N bond formation reaction of benzenesulfonamides with sulfonyl azides. The amidation reaction provides a protocol for the synthesis of 2-aminobenzesulfonamides in good to excellent yields. This strategy features a wide substrate scope, tolerates a broad range of functional groups under external oxidant-free conditions and only releases molecular nitrogen as the sole by-product. Moreover, the preliminary mechanism was investigated and the proposed reaction pathway was provided. (Figure presented.).
Synthesis of benzofused five-ring sultams via Rh-catalyzed C-H olefination directed by an N -Ac-substituted sulfonamide group
Li, Xueyuan,Dong, Yi,Qu, Fengyu,Liu, Gang
, p. 790 - 798 (2015/03/05)
A Rh-catalyzed N-Ac-sulfonamide group directed C-H olefination-cyclization to afford benzofused five-ring sultam is described with high yield and a wide range of substrate scope. The N-acetyl group is a key for this transformation implying that N-H acidit
Regioselective ortho olefination of aryl sulfonamide via rhodium-catalyzed direct C-H bond activation
Xie, Weijia,Yang, Jie,Wang, Baiquan,Li, Bin
, p. 8278 - 8287 (2015/03/18)
Rh(III)-catalyzed ortho C-H olefination of aryl sulfonamide directed by the SO2NHAc group is reported. This oxidative coupling process is achieved highly efficiently and selectively with a broad substrate scope. The reactions of N-tosylacetamid
Design, synthesis, and biological evaluation of N-acetyl-2- carboxybenzenesulfonamides: A novel class of cyclooxygenase-2 (COX-2) inhibitors
Chen, Qiao-Hong,Rao, P. N. Praveen,Knaus, Edward E.
, p. 2459 - 2468 (2007/10/03)
N-Acetyl-2-carboxybenzenesulfonamide (11), and a group of analogues possessing an appropriately substituted-phenyl substituent (4-F, 2,4-F 2, 4-SO2Me, 4-OCHMe2) attached to its C-4, or C-5 position, were synthesized for ev
