272129-68-7

Upstream product

• 272129-64-3 tert-butyl (2S)-2-(1,3-benzothiazol-2-ylcarbonyl)-pyrrolidine-1-carboxylate 
• 272129-66-5 1-(benzothiazol-2-yl)-1-<1-(tert-butyloxycarbonyl)-2(S)-pyrrolidinyl>methanol 
• 115186-37-3 tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate 
• 95-16-9 1,3-Benzothiazole 
• 2706-38-9 N-(N-benzyloxycarbonyl-L-leucyl)-glycine 

Relevant academic research and scientific papers

Synthesis and activity of pyrrolidinyl- and thiazolidinyl-dipeptide derivatives as inhibitors of the Tc80 prolyl oligopeptidase from Trypanosoma cruzi

Pyrrolidinyl- and thiazolidinyl- dipeptide derivatives, featuring either a vinyl sulfone-, a 2-ketobenzothiazole-, a nitrile-, or a benzimidazole group at the C-terminus, were designed and synthesized as potential inhibitors of the prolyl-specific Tc80 proteinase from Trypanosoma cruzi, the agent of Chagas' disease. These compounds were evaluated in vitro towards the target enzyme which was classified as a serine protease belonging to the prolyl oligopeptidase family (EC 3.4.21.26). A peptidyl nitrile and two peptidyl α-ketobenzothiazoles were shown to be potent reversible and competitive inhibitors of Tc 80 proteinase, with K(i) values in the range 38- 219 nM, and compared advantageously with some known mammalian prolyl oligopeptidase inhibitors. (C) 2000 Editions scientifiques et medicales Elsevier SAS.