27215-14-1 Usage
Description
Andrographic plants are derived from the aerial parts of Andrographis paniculata
(Burm.f.) Nees and known by various vernacular names such as “chunlianqiuliu,”
“yijianxi,” “lanhelian,” “kudancao,” “jinxiangcao,” “jinergou,” “India grass,” and
“bitter grass.” Andrographis paniculata is planted in South and Southeast Asia,
India, and Australia. This herb is also cultivated in Fujian, Guangdong, Hainan,
Guangxi, Yunnan, Jiangsu, and Shaanxi provinces in China. Andrographis paniculata has been used to treat colds, sore throat, mouth sores, cough, diarrhea dysentery, and so on. Andrographis paniculata contains diterpene lactone compounds,
and they have anti-inflammatory and antimicrobial activities. The main active ingredients include andrographolide, neoandrographolide, deoxy andrographolide, dehydrated andrographolide, and so on. Andrographis paniculata has been included by
US Pharmacopeia.
Physical properties
Appearance: Neoandrographolide is a colorless column crystal that has been isolated from the stem and leaves of Andrographis paniculata. Melting point: 167–
168?°C. Specific optical rotation: ?48°(pyridine); ?45°(c?=?1, absolute ethanol).
Solubility: Soluble in methanol, ethanol, acetone, and pyridine and slightly soluble
in chloroform and water but insoluble in ether and petroleum ether.
History
The chemical constituents of Andrographis paniculata are mainly lactones and flavonoids, including the lactone compounds such as andrographolide and dehydrated
andrographolide. In 1952, Kleipool first reported the separation of andrographolide
from Andrographis paniculata . In 1968 and 1971, W.?R. Chan et?al. identified
the chemical structure and stereostructure of andrographolide. In the 1990s, a variety of diterpene lactones were isolated from the aerial part and the lotus leaf of
Andrographis paniculata, such as andrographolide, neoandrographolide, dehydroandrographolide, deoxyandrographolid, deoxyandrographiside,
8-methylandrograpanin, 3-dehydrodeoxyandrographolide, andrograpanin, and
3-oxo-14-deoxy-andrographol,and also some flavonoids and sitosterol and daucosterol compounds . Until now, more than 40 diterpene lactone components and
more than 70 flavonoids have been found from Andrographis paniculata. There are
sterols, organic acids, diterpene alcohols, diterpene acid salts, and cycloalkene ether
also found from Andrographis paniculata .Since the 1970s, pharmacists and organic chemists have done a lot of work on
the modification of andrographolide, mainly in Michael addition of α, β-unsaturated
lactone double bonds and three hydroxyl groups selective esterification, oxidation
and substitution reactions, redox reduction of double bonds, intramolecular cyclization, and lactone ring replacement reactions , and the resulting andrographolide
derivatives or analogues can improve the antibacterial, anti-inflammatory, cardiovascular system, immunomodulation, and antitumor activities.
Uses
Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia.
Indications
Neoandrographolide is available in the Pharmacopoeia of the People’s Republic of
China (1977).Neoandrographolide and andrographolide are the main active ingredients of a
variety of pharmaceutical preparations containing the Andrographis herb, such as
andrographolide capsules, andrographolide tablets, Andrographis injection, potassium dehydroandrographolide succinate injection, Andrographis tablets, Xiaoyan
Lidan tablets, and Fufang chuan xin lian tablets. These drugs are mainly used for
treating acute bacterial dysentery, acute gastroenteritis, upper respiratory tract
infection, acute tonsillitis, pharyngitis, etc. In addition, they are also used to treat
malignant hydatidiform mole and choriocarcinoma.
Pharmacology
Andrographis paniculata has detoxifying abilities, reduces swelling, and relieves
pain. The four major diterpene lactones in Andrographis paniculata have antipyretic
and anti-inflammatory activities against 2,4-dinitrophenol or endotoxin-induced
fever and egg white-induced edema or croton oil-induced inflammatory models.Animal experiments have shown that Andrographis paniculata has inhibited and
delayed the body temperature elevation of persons with infections caused by pneumococcus and hemolytic streptococcus. It also can be used for treating cough and
asthma and especially for treating acute bacterial dysentery, acute gastroenteritis,
upper respiratory tract infection, acute tonsillitis, pharyngitis, and so on.The active ingredients andrographolide and neoandrographolide inhibit
lipopolysaccharide-induced NO production in the mouse peritoneal macrophages
. Neoandrographolide at the high concentration can inhibit the macrophage outbreak caused by LPS and the proliferation of lymphocytes and can synergistically
enhance the PMA stimulating effect on the respiratory outbreak. The possible
mechanism is related to its ROS scavenging activity .
Clinical Use
Neoandrographolide is one of the main active ingredients of the natural plant
Andrographis paniculata. But there is no formulation of neoandrographolide.
Andrographis injection has been clinically used, but it has several side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 27215-14-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,2,1 and 5 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 27215-14:
(7*2)+(6*7)+(5*2)+(4*1)+(3*5)+(2*1)+(1*4)=91
91 % 10 = 1
So 27215-14-1 is a valid CAS Registry Number.
InChI:InChI=1/C26H40O8/c1-15-5-8-19-25(2,14-33-24-22(30)21(29)20(28)18(13-27)34-24)10-4-11-26(19,3)17(15)7-6-16-9-12-32-23(16)31/h9,17-22,24,27-30H,1,4-8,10-14H2,2-3H3/t17-,18-,19-,20-,21+,22-,24-,25+,26+/m1/s1
27215-14-1Relevant articles and documents
Glucosyltransferase Capable of Catalyzing the Last Step in Neoandrographolide Biosynthesis
Li, Yuan,Lin, Hui-Xin,Wang, Jian,Yang, Jian,Lai, Chang-Jiang-Sheng,Wang, Xing,Ma, Bao-Wei,Tang, Jin-Fu,Li, Yong,Li, Xin-Lin,Guo, Juan,Gao, Wei,Huang, Lu-Qi
supporting information, p. 5999 - 6002 (2018/10/20)
ApUGT, a diterpene glycosyltransferase from Andrographis paniculata, could transfer a glucose to the C-19 hydroxyl moiety of andrograpanin to form neoandrographolide. This glycosyltransferase has a broad substrate scope, and it can glycosylate 26 natural and unnatural compounds of different structural types. This study provides a basis for exploring the glycosylation mechanism of ent-labdane-type diterpenes and plays an important role in diversifying the structures used in drug discovery.
