27231-25-0

Upstream product

• 6967-12-0 6-amino-1H-indazole 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 144588-49-8 9-chloro-7-methyl-1H-pyrazolo<3,4-f>quinoline 
• 144588-46-5 9-m-anisidino-7-methyl-1H-pyrazolo<3,4-f>quinoline hydrochloride 

Relevant academic research and scientific papers

Structure-activity relationships of imidazo[4,5-f]quinoline partial structures and analogs. Discovery of pyrazolo[3,4-f]quinoline derivatives as potent immunostimulants

Structure-activity studies have been carried out on a series of imidazo[4,5-f]quinoline derivatives reported to have potent in vivo immunostimulatory activity. This activity has been confirmed, and subtle structure-activity relationships have been uncovered which resulted in the identification of novel analogs (pyrazolo[3,4-f]quinoline derivatives, 7a,b) with potent in vivo effects in a mouse protection model. Regioisomeric pyrazolo[4,3-f]quinoline derivatives (6a,b) were shown to be inactive. Data are presented which support the notion that the in vivo activity is mediated by an immunostimulatory mechanism.

Quinoline derivatives as immunostimulants

This invention relates to compounds of the formula STR1 wherein R1, R2, R3, R4, R5, R6 and R7 are as defined hereinbelow that exhibit activity as immunostimulants.