27242-80-4Relevant academic research and scientific papers
Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives
Gürdere, Meliha Burcu,Kamo, Erdo?an,?ahin Ya?lio?lu, Ay?e,Budak, Yakup,Ceylan, Mustafa
, p. 263 - 271 (2017/05/29)
A series of 1,4-phenylene-bis-chalcones 3a{3h were synthesized by the reaction of terephthalaldehyde with substituted arylketones in this study. The novel 1,4-phenylene-bis-pyrimidine-2-amine derivatives 5a{5h were obtained by the addition of guanidine hy
Aluminum chloride-catalyzed C-alkylation of pyrrole and indole with chalcone and bis-chalcone derivatives
Gürdere, Meliha Burcu,?zbek, Oguz,Ceylan, Mustafa
supporting information, p. 322 - 331 (2016/03/23)
The AlCl3-catalyzed alkylation of pyrrole (2) with chalcone (1a-i) at a ratio of 8:1 in the presence of 10 mol% AlCl3 gave the solely 2-alkyl pyrroles (3a-i) at room temperature for 12 in good yields. The same reaction was performed with pyrrole (2) and chalcone at a ratio of 1:3 in CH3CN at rt for 3 h to achieve 2,5-dialkyl pyrroles (4a-f). In addition, the reaction of the pyrrole (2) and indole (7) on 1,4-phenylene bis-chalcones (5a-g) at the ratio of 8:1 at rt for 24 h gave the double-addition products 6a-g and 8a-g in good yields, respectively. The structure of the products was confirmed by 1H and 13C NMR spectroscopy and elemental analysis.
