27247-34-3

Usage

Uses

Used in Pharmaceutical Industry:
Potassium 5-(Methoxycarbonyl)nicotinate is used as an intermediate in the synthesis of Nornicotine (N757000) analogs. These analogs are employed as haptens for immunoassays, which are essential tools in the detection and measurement of specific substances, particularly in the fields of drug testing, medical diagnostics, and environmental monitoring.
Used in Chemical Synthesis:
In the chemical industry, Potassium 5-(Methoxycarbonyl)nicotinate is utilized as a key intermediate in the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its ability to form salts and esters makes it a valuable building block in the development of new molecules with potential applications in various industries.

Upstream product

• 499-81-0 3,5-Pyridinedicarboxylic acid 
• 4591-55-3 dimethyl pyridine-3,5-dicarboxylate 

Relevant academic research and scientific papers

A predictive model for additions to: N -alkyl pyridiniums

Disclosed in this communication is a thorough study on the dearomative addition of organomagnesium nucleophiles to N-alkyl pyridinium electrophiles. The regiochemical outcomes have observable and predictable trends associated with the substituent patterns on the pyridinium electrophile. Often, the substituent effects can be either additive, giving high selectivities, or ablative, giving competing outcomes. Additionally, the nature of the organometallic nucleophilic component was also investigated for its role in the regioselective outcome. The effects of either reactive component are important to both the overall reactivity and site of nucleophilic addition. The utility of these observed trends is demonstrated in a concise, dearomative synthesis of a tricyclic compound shown to have insecticidal activity. This journal is

PYRROLIDINE DERIVATIVE OR SALT THEREOF

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).