2725-13-5Relevant academic research and scientific papers
3-Tertiary amino-1-aryloxy- or aryl-propanes and -propan -2-ols and some related compounds
Gupta,Mukerji,Chatterjee,Rastogi,Anand,Dube,Sur Jr.,Mukerji,Srimal
, p. 241 - 246 (2007/10/04)
The synthesis and pharmacological activity of some 3 tertiary amino 1 aryloxy or 1 aryl, 1 thiophenoxy and 1 anilino propan 2 ols and propanes, particularly those derived from N phenylpiperazines are described. Effect of substituents (nature/position) on the phenyl ring, the phenoxy ring as well as alteration in the hydroxylic function vis a vis the structure activity relationships (SAR) are discussed. In general, the 1 aryloxy compounds have hypotensive activity this being more pronounced in those carrying an o substituent on the phenyl ring, while m and p substituted derivatives have their effect primarily on the CNS. Variations in the phenoxy moiety do not significantly alter the intrinsic activity. The 1 aryl compounds, on the other hand, have significant CNS activity, which is markedly affected by the substituents on the 1 aryl residue.
