27277-83-4Relevant academic research and scientific papers
A mild and efficient copper-mediated N-arylation of 6-azauracil with corresponding boronic acids and their antibacterial activity
Gulipalli, Kali Charan,Bodige, Srinu,Ravula, Parameshwar,Bolla, R. Sekhar,Endoori, Srinivas,Cherukumalli, Purna Koteswara Rao,Seelam, Nareshvarma
, p. 2495 - 2501 (2018)
A convenient synthetic strategy is reported for the synthesis of N-arylated 6-azauracil through Chan-Lam cross-coupling. A variety of N-arylated 6-azauracil derivatives were synthesized in moderate to good yields by cross-coupling of 6-azauracil with arylboronic acids in the presence of Cu(OAc)2 and pyridine. However the arylation position is confirmed in the case of 2-(3,5-dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione (3a), by preparing the compound in a traditional method and compared the chemical shift of the NH proton at N-3 position. Further, the synthesized compounds were screened for their antibacterial activity using agar well diffusion method. The results revealed that most of the synthesized moieties possessing promising therapeutic nature.
