272785-86-1

Basic information

• Product Name: 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(5-nitropyridyl-2-disulfanyl)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine
• CAS NO: 272785-86-1
• Molecular Weight: 811.027
• Mol File: 272785-86-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(5-nitropyridyl-2-disulfanyl)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(5-nitropyridyl-2-disulfanyl)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine(272785-86-1)
• EPA Substance Registry System: 9-[5-O-(monomethoxytrityl)-3-deoxy-3-thio-3-S-(5-nitropyridyl-2-disulfanyl)-2-O-(isopropydimethylsilyl)-β-D-ribofuranosyl]hypoxanthine(272785-86-1)

Safety Data

• Hazardous Substances Data: 272785-86-1(Hazardous Substances Data)

Upstream product

• 3634-56-8 isopropyldimethylsilyl chloride 
• 174467-01-7 9-[(2R,3S,4S,5R)-3-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-4-(5-nitro-pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one 

Relevant articles and documents

Preparation, hydrolysis and intramolecular transesterification of 3'- deoxy-3'-thioinosine 3'-S-dimethylphosphorothiolate

The hydrolytic reactions of the dimethyl ester of 3'-deoxy-3'- thioinosine 3'-S-phosphorothiolate have been followed over a wide acidity range by HPLC. At pH > 3, only hydroxide ion catalyzed isomerization to the 2'-dimethylphosphate takes place, whereas under more acidic conditions hydrolysis to the 2'-monomethylphosphate and 3'-S-monomethylphosphorothiolate competes. The latter is the only product accumulating in very acidic solutions (1 M hydrochloric acid). Mechanisms of the reactions are discussed.