272786-26-2

Upstream product

• 24856-58-4 1,1-dimethoxy-1-(4-bromophenyl)methane 
• 228267-20-7 tert-butyl (R)-4-((tert-butyldimethylsilyl)oxy)-2-oxopyrrolidine-1-carboxylate 

Downstream Products

• 360579-41-5 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-dimethoxymethyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 228267-22-9 (2R,4R)-1-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-(4-formylphenyl)pyrrolidine 
• 312297-44-2 (1S,3R)-4-tert-butoxycarbonylamino-3-tert-butyldimethylsiloxy-1-(4-dimethoxymethylphenyl)butanol 

Relevant academic research and scientific papers

Diastereoselective synthesis of (2R,4R)-2-aryl-4-hydroxypyrrolidine: Preparation of the side chain of novel carbapenem

Improved synthesis of the trans-3,5-disubstituted pyrrolidin-3-ylthio side-chain of the novel carbapenem 1 was achieved via stereoselective reduction of the 1-aryl-1-butanone derivative 5 and successive intramolecular cyclization of the resulting chiral alcohol 6. The 1-aryl-1-butanone derivative 5 was obtained by a coupling reaction of protected 4-hydroxy-2-pyrrolidone with aryl-Grignard reagent.