272787-07-2

Upstream product

• 272787-05-0 (3R,3aR,7aS)-3-(S)-1,4-Dioxa-spiro[4.5]dec-2-yl-3a-hydroxy-7a-trimethylsilanyloxy-3a,4,7,7a-tetrahydro-3H-isobenzofuran-1-one 
• 272787-01-6 4-allyloxy-5-(1,4-dioxa-spiro[4.5]dec-2-yl)-3-hydroxy-5H-furan-2-one 
• 272787-04-9 (3S,4R,5R)-3,4-Diallyl-5-(S)-1,4-dioxa-spiro[4.5]dec-2-yl-4-hydroxy-3-trimethylsilanyloxy-dihydro-furan-2-one 
• 272787-03-8 (3S,5R)-3-Allyl-5-(S)-1,4-dioxa-spiro[4.5]dec-2-yl-3-trimethylsilanyloxy-furan-2,4-dione 
• 6614-52-4 5,6-O-cyclohexylidene-L-ascorbic acid 
• 272787-06-1 (Z)-(R)-(S)-9-(1,4-Dioxa-spiro[4.5]dec-2-yl)-4,7-dihydro-oxonine-2,3,8-trione 

Downstream Products

• 272787-11-8 Benzoic acid (Z)-(3R,9R)-9-(S)-1,4-dioxa-spiro[4.5]dec-2-yl-2,8-dioxo-2,3,4,7,8,9-hexahydro-oxonin-3-yl ester 

Relevant academic research and scientific papers

Synthesis of a ring F building block for the ciguatoxins

The preparation of a new ring F building block for the marine polyether toxins, the ciguatoxins, employing ascorbic acid as a chiral pool starting material, is reported.

The vitamin C route to the ciguatoxins: Enantioselective synthesis of a ring F building block

A ten-step enantioselective synthesis of an F ring lactone for CTX antibody assay development, employing vitamin C as a starting material, is described.