272787-49-2Relevant academic research and scientific papers
α-Thiosubstituted chiral imines/secondary enamines: Their use in the asymmetric Michael reaction
Nour, Mohammed,Tan, Kimny,Cave, Christian,Villeneuve, David,Desmaele, Didier,D'Angelo, Jean,Riche, Claude
, p. 995 - 1002 (2000)
The asymmetric Michael reaction between 2-thiosubstituted chiral imines/secondary enamines derived from (S)-1-phenylethylamine and electrophilic alkenes (methyl acrylate, MVK) was investigated. 2-Phenylthio derivatives furnished the expected Michael adducts with excellent ee. By contrast, an in situ elimination of p-toluenesulfenic acid took place when using the p-toluenesulfinyl analogs. Copyright (C) 2000 Elsevier Science Ltd.
