272787-67-4

Upstream product

• 272787-58-3 acetic acid 2-[6-(2,2-dimethyl-[1,3]dioxolan-4-yl)-5-methoxy-2-methylenehex-3-ynyl]tetrahydropyran-3-yl ester 
• 272787-65-2 Acetic acid (2R,3S)-2-((S)-7,8-dihydroxy-5-methoxy-2-methylene-oct-3-ynyl)-tetrahydro-pyran-3-yl ester 
• 272787-57-2 4-(2-methoxybut-3-ynyl)-2,2-dimethyl-[1,3]dioxolane 
• 272787-64-1 1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-4-trimethylsilylbut-3-yn-2-ol 
• 272787-66-3 acetic acid 2-[8-(tert-butyldiphenylsilyl)-7-hydroxy-5-methoxy-2-methyleneoct-3-ynyl]tetrahydropyran-3-yl ester 

Relevant academic research and scientific papers

Synthesis of the H-I-J tricyclic fragment of ciguatoxin, a marine polyether toxin

During the course of our synthetic studies on ciguatoxin, synthesis of H-I-J tricyclic fragment has been stereoselectively achieved starting from a D-glucal derivative. The key steps are Sonogashira coupling reaction and cobalt complex-mediated oxocane cyclization.