272788-85-9Relevant academic research and scientific papers
New thymine-based derivative of nitrogen mustards
Boens, Benjamin,Teste, Karine,Hadj-Bouazza, Amel,Ismaili, Jihane,Zerrouki, Rachida
, p. 197 - 205 (2012)
This work deals with the synthesis of a new nitrogen mustard derivative based on thymine. To introduce the bis(2-chloroethyl)amine group to position 4 of the pyrimidine base, many strategies were explored and the desired compound was finally obtained, thanks to a synthetic pathway in five steps. Copyright Taylor and Francis Group, LLC.
Design of a new oligotriazole peptide nucleic acid analogue (oT-PNA)
Vergnaud, Julien,Faugeras, Pierre-Antoine,Chaleix, Vincent,Champavier, Yves,Zerrouki, Rachida
, p. 6185 - 6189 (2011)
We describe in this Letter the synthesis of an original thymine azido-heterotrimer generated by Click Chemistry. This trimer has been obtained from an azido-thymidine and a new chloroethyl-propargylated PNA monomer analogue, after two azidation/click-reaction cycles. Conformational preferences of a rotameric intermediate have also been studied.
Synthesis and hybridization properties of DNA-PNA chimeras carrying 5- bromouracil and 5-methylcytosine
Ferrer, Elisenda,Shevchenko, Anna,Eritja, Ramon
, p. 291 - 297 (2007/10/03)
The preparation of 5-bromouracil and 5-methylcytosine peptide nucleic acid (PNA) monomers is described. These PNA monomers were used for the preparation of several DNA-PNA chimeras and their hybridization properties are described. The substitution of cyto
